Plausible mechanisms of Niclosamide as an antiviral agent against COVID-19

Corona virus disease 2019 (COVID-19) pandemic caused 18 440 deaths world wide as of 25 March 2020 and posing a serious threat to public health. There is a need, therefore, for effective therapeutic strategies to cure this disease. However, high attrition rates, substantial costs and slow pace are th...

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Detalles Bibliográficos
Autores principales: Pindiprolu, Sai Kiran S.S., Pindiprolu, Sai Harshini
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7195103/
https://www.ncbi.nlm.nih.gov/pubmed/32361588
http://dx.doi.org/10.1016/j.mehy.2020.109765
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author Pindiprolu, Sai Kiran S.S.
Pindiprolu, Sai Harshini
author_facet Pindiprolu, Sai Kiran S.S.
Pindiprolu, Sai Harshini
author_sort Pindiprolu, Sai Kiran S.S.
collection PubMed
description Corona virus disease 2019 (COVID-19) pandemic caused 18 440 deaths world wide as of 25 March 2020 and posing a serious threat to public health. There is a need, therefore, for effective therapeutic strategies to cure this disease. However, high attrition rates, substantial costs and slow pace are the major limitations of novel drug discovery. Drug repurposing, by employing ‘old’ drugs to treat ‘new’ diseases is an attractive approach in drug discovery. Niclosamide (NIC) is an approved anti-helminthic drug with diverse antiviral mechanisms. In this work we hypothesize, the potential antiviral mechanisms of NIC against COVID-19.
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spelling pubmed-71951032020-05-02 Plausible mechanisms of Niclosamide as an antiviral agent against COVID-19 Pindiprolu, Sai Kiran S.S. Pindiprolu, Sai Harshini Med Hypotheses Article Corona virus disease 2019 (COVID-19) pandemic caused 18 440 deaths world wide as of 25 March 2020 and posing a serious threat to public health. There is a need, therefore, for effective therapeutic strategies to cure this disease. However, high attrition rates, substantial costs and slow pace are the major limitations of novel drug discovery. Drug repurposing, by employing ‘old’ drugs to treat ‘new’ diseases is an attractive approach in drug discovery. Niclosamide (NIC) is an approved anti-helminthic drug with diverse antiviral mechanisms. In this work we hypothesize, the potential antiviral mechanisms of NIC against COVID-19. Elsevier Ltd. 2020-07 2020-04-22 /pmc/articles/PMC7195103/ /pubmed/32361588 http://dx.doi.org/10.1016/j.mehy.2020.109765 Text en © 2020 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Pindiprolu, Sai Kiran S.S.
Pindiprolu, Sai Harshini
Plausible mechanisms of Niclosamide as an antiviral agent against COVID-19
title Plausible mechanisms of Niclosamide as an antiviral agent against COVID-19
title_full Plausible mechanisms of Niclosamide as an antiviral agent against COVID-19
title_fullStr Plausible mechanisms of Niclosamide as an antiviral agent against COVID-19
title_full_unstemmed Plausible mechanisms of Niclosamide as an antiviral agent against COVID-19
title_short Plausible mechanisms of Niclosamide as an antiviral agent against COVID-19
title_sort plausible mechanisms of niclosamide as an antiviral agent against covid-19
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7195103/
https://www.ncbi.nlm.nih.gov/pubmed/32361588
http://dx.doi.org/10.1016/j.mehy.2020.109765
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