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Ultrastructural visualization of 3D chromatin folding using volume electron microscopy and DNA in situ hybridization
The human genome is extensively folded into 3-dimensional organization. However, the detailed 3D chromatin folding structures have not been fully visualized due to the lack of robust and ultra-resolution imaging capability. Here, we report the development of an electron microscopy method that combin...
Autores principales: | , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7195386/ https://www.ncbi.nlm.nih.gov/pubmed/32358536 http://dx.doi.org/10.1038/s41467-020-15987-2 |