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Alternative splicing controls teneurin-latrophilin interaction and synapse specificity by a shape-shifting mechanism

The trans-synaptic interaction of the cell-adhesion molecules teneurins (TENs) with latrophilins (LPHNs/ADGRLs) promotes excitatory synapse formation when LPHNs simultaneously interact with FLRTs. Insertion of a short alternatively-spliced region within TENs abolishes the TEN-LPHN interaction and sw...

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Detalles Bibliográficos
Autores principales:	Li, Jingxian, Xie, Yuan, Cornelius, Shaleeka, Jiang, Xian, Sando, Richard, Kordon, Szymon P., Pan, Man, Leon, Katherine, Südhof, Thomas C., Zhao, Minglei, Araç, Demet
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7195488/ https://www.ncbi.nlm.nih.gov/pubmed/32358586 http://dx.doi.org/10.1038/s41467-020-16029-7

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