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Systemic short chain fatty acids limit antitumor effect of CTLA-4 blockade in hosts with cancer

Gut microbiota composition influences the clinical benefit of immune checkpoints in patients with advanced cancer but mechanisms underlying this relationship remain unclear. Molecular mechanism whereby gut microbiota influences immune responses is mainly assigned to gut microbial metabolites. Short-...

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Detalles Bibliográficos
Autores principales:	Coutzac, Clélia, Jouniaux, Jean-Mehdi, Paci, Angelo, Schmidt, Julien, Mallardo, Domenico, Seck, Atmane, Asvatourian, Vahe, Cassard, Lydie, Saulnier, Patrick, Lacroix, Ludovic, Woerther, Paul-Louis, Vozy, Aurore, Naigeon, Marie, Nebot-Bral, Laetitia, Desbois, Mélanie, Simeone, Ester, Mateus, Christine, Boselli, Lisa, Grivel, Jonathan, Soularue, Emilie, Lepage, Patricia, Carbonnel, Franck, Ascierto, Paolo Antonio, Robert, Caroline, Chaput, Nathalie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7195489/ https://www.ncbi.nlm.nih.gov/pubmed/32358520 http://dx.doi.org/10.1038/s41467-020-16079-x

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