New Synthetic 3-Benzoyl-5-Hydroxy-2H-Chromen-2-One (LM-031) Inhibits Polyglutamine Aggregation and Promotes Neurite Outgrowth through Enhancement of CREB, NRF2, and Reduction of AMPKα in SCA17 Cell Models

Spinocerebellar ataxia type 17 (SCA17) is caused by a CAG/CAA expansion mutation encoding an expanded polyglutamine (polyQ) tract in TATA-box binding protein (TBP), a general transcription initiation factor. Suppression of cAMP-responsive element binding protein- (CREB-) dependent transcription, imp...

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Detalles Bibliográficos
Autores principales: Chen, Chiung-Mei, Chen, Wan-Ling, Yang, Shu-Ting, Lin, Te-Hsien, Yang, Shu-Mei, Lin, Wenwei, Chao, Chih-Ying, Wu, Yih-Ru, Chang, Kuo-Hsuan, Lee-Chen, Guey-Jen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7195640/
https://www.ncbi.nlm.nih.gov/pubmed/32377295
http://dx.doi.org/10.1155/2020/3129497

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