Cyclin-dependent kinases and CDK inhibitors in virus-associated cancers

The role of several risk factors, such as pollution, consumption of alcohol, age, sex and obesity in cancer progression is undeniable. Human malignancies are mainly characterized by deregulation of cyclin-dependent kinases (CDK) and cyclin inhibitor kinases (CIK) activities. Viruses express some onc...

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Autores principales: Tavakolian, Shaian, Goudarzi, Hossein, Faghihloo, Ebrahim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7195796/
https://www.ncbi.nlm.nih.gov/pubmed/32377232
http://dx.doi.org/10.1186/s13027-020-00295-7
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author Tavakolian, Shaian
Goudarzi, Hossein
Faghihloo, Ebrahim
author_facet Tavakolian, Shaian
Goudarzi, Hossein
Faghihloo, Ebrahim
author_sort Tavakolian, Shaian
collection PubMed
description The role of several risk factors, such as pollution, consumption of alcohol, age, sex and obesity in cancer progression is undeniable. Human malignancies are mainly characterized by deregulation of cyclin-dependent kinases (CDK) and cyclin inhibitor kinases (CIK) activities. Viruses express some onco-proteins which could interfere with CDK and CIKs function, and induce some signals to replicate their genome into host’s cells. By reviewing some studies about the function of CDK and CIKs in cells infected with oncoviruses, such as HPV, HTLV, HERV, EBV, KSHV, HBV and HCV, we reviewed the mechanisms of different onco-proteins which could deregulate the cell cycle proteins.
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spelling pubmed-71957962020-05-06 Cyclin-dependent kinases and CDK inhibitors in virus-associated cancers Tavakolian, Shaian Goudarzi, Hossein Faghihloo, Ebrahim Infect Agent Cancer Review The role of several risk factors, such as pollution, consumption of alcohol, age, sex and obesity in cancer progression is undeniable. Human malignancies are mainly characterized by deregulation of cyclin-dependent kinases (CDK) and cyclin inhibitor kinases (CIK) activities. Viruses express some onco-proteins which could interfere with CDK and CIKs function, and induce some signals to replicate their genome into host’s cells. By reviewing some studies about the function of CDK and CIKs in cells infected with oncoviruses, such as HPV, HTLV, HERV, EBV, KSHV, HBV and HCV, we reviewed the mechanisms of different onco-proteins which could deregulate the cell cycle proteins. BioMed Central 2020-05-01 /pmc/articles/PMC7195796/ /pubmed/32377232 http://dx.doi.org/10.1186/s13027-020-00295-7 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Tavakolian, Shaian
Goudarzi, Hossein
Faghihloo, Ebrahim
Cyclin-dependent kinases and CDK inhibitors in virus-associated cancers
title Cyclin-dependent kinases and CDK inhibitors in virus-associated cancers
title_full Cyclin-dependent kinases and CDK inhibitors in virus-associated cancers
title_fullStr Cyclin-dependent kinases and CDK inhibitors in virus-associated cancers
title_full_unstemmed Cyclin-dependent kinases and CDK inhibitors in virus-associated cancers
title_short Cyclin-dependent kinases and CDK inhibitors in virus-associated cancers
title_sort cyclin-dependent kinases and cdk inhibitors in virus-associated cancers
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7195796/
https://www.ncbi.nlm.nih.gov/pubmed/32377232
http://dx.doi.org/10.1186/s13027-020-00295-7
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