RNA-binding protein IGF2BP1 maintains leukemia stem cell properties by regulating HOXB4, MYB, and ALDH1A1.

Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) is an oncofetal protein expressed in various cancers including leukemia. In this study, we assessed the role of IGF2BP1 in orchestrating leukemia stem cell properties. Tumor-initiating potential, sensitivity to chemotherapeutic agents and...

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Detalles Bibliográficos
Autores principales: Elcheva, Irina A., Wood, Tyler, Chiarolanzio, Kathryn, Chim, Bryan, Wong, Madeline, Singh, Vikash, Gowda, Chethana P., Lu, Qingli, Hafner, Markus, Dovat, Sinisa, Liu, Zhenqiu, Muljo, Stefan A., Spiegelman, Vladimir S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7196026/
https://www.ncbi.nlm.nih.gov/pubmed/31768017
http://dx.doi.org/10.1038/s41375-019-0656-9

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