Tamoxifen is a candidate first‐in‐class inhibitor of acid ceramidase that reduces amitotic division in polyploid giant cancer cells—Unrecognized players in tumorigenesis

Polyploid giant cancer cells (PGCC) represent a poorly understood, small subpopulation of tumor cells that are increasingly being recognized for their critical role in therapy resistance, metastasis, and cancer recurrence. PGCC have the potential to generate progeny through primitive or cleavage‐lik...

Descripción completa

Detalles Bibliográficos
Autores principales: White‐Gilbertson, Shai, Lu, Ping, Jones, Christian M., Chiodini, Stephanie, Hurley, Deborah, Das, Arabinda, Delaney, Joe R., Norris, James S., Voelkel‐Johnson, Christina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7196070/
https://www.ncbi.nlm.nih.gov/pubmed/32135040
http://dx.doi.org/10.1002/cam4.2960

Ejemplares similares

Ejemplares similares