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Cryo-EM structures of PAC1 receptor reveal ligand binding mechanism

The pituitary adenylate cyclase-activating polypeptide type I receptor (PAC1R) belongs to the secretin receptor family and is widely distributed in the central neural system and peripheral organs. Abnormal activation of the receptor mediates trigeminovascular activation and sensitization, which is h...

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Detalles Bibliográficos
Autores principales:	Wang, Jia, Song, Xianqiang, Zhang, Dandan, Chen, Xiaoqing, Li, Xun, Sun, Yaping, Li, Cui, Song, Yunpeng, Ding, Yao, Ren, Ruobing, Harrington, Essa Hu, Hu, Liaoyuan A., Zhong, Wenge, Xu, Cen, Huang, Xin, Wang, Hong-Wei, Ma, Yingli
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Singapore 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7196072/ https://www.ncbi.nlm.nih.gov/pubmed/32047270 http://dx.doi.org/10.1038/s41422-020-0280-2

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