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Circulating miR-34a and Bone Mineral Density of Brazilian Very-Old Adults

The human aging is marked by several body changes, including in bone mineral density (BMD). Research shows that microRNAs are important modulators of bone metabolism. The present research aims to analyze the whole blood concentration of 10 selected microRNAs (miRs) and their association with absolut...

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Autores principales: Nóbrega, Otávio T., Morais-Junior, Gilberto S., Viana, Nayara I., Reis, Sabrina T., Perez, Diego I. V., Freitas, Wladimir M., Sposito, Andrei C., Leite, Kátia R. M., Srougi, Miguel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7196151/
https://www.ncbi.nlm.nih.gov/pubmed/32377434
http://dx.doi.org/10.1155/2020/3431828
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author Nóbrega, Otávio T.
Morais-Junior, Gilberto S.
Viana, Nayara I.
Reis, Sabrina T.
Perez, Diego I. V.
Freitas, Wladimir M.
Sposito, Andrei C.
Leite, Kátia R. M.
Srougi, Miguel
author_facet Nóbrega, Otávio T.
Morais-Junior, Gilberto S.
Viana, Nayara I.
Reis, Sabrina T.
Perez, Diego I. V.
Freitas, Wladimir M.
Sposito, Andrei C.
Leite, Kátia R. M.
Srougi, Miguel
author_sort Nóbrega, Otávio T.
collection PubMed
description The human aging is marked by several body changes, including in bone mineral density (BMD). Research shows that microRNAs are important modulators of bone metabolism. The present research aims to analyze the whole blood concentration of 10 selected microRNAs (miRs) and their association with absolute and relative scores of BMD in specific osseous site of Brazilian very-old adults. Forty noninstitutionalized and apparently healthy, very old (≥80 years) outpatients were eligible for research. Anthropometry, biochemistry, and densitometry measurements were performed along with coronary artery calcification (CAC) scores and tested across total circulating levels of microRNAs. As expected, the relative BMD scores for the lumbosacral region (L1 to S5) and for the femoral head and neck observed in the sample denote weakened bone architecture, compatible with prevalent osteopenia and osteoporosis. In this context, one single significant association was found, and negatively implicated the miR-34a-5p with both absolute (β = −0.36, P=0.001 for BMD) and relative (β = −0.43, P=0.001 for T-score) densitometry indexes of the femoral head (adjusted to sex and physical activity practice), but not with the other sites. No difference in total blood concentrations of the miRs was found according to CAC scores. Our findings indicate greater circulating levels for miR-34a-5p among very-old adults who display the lowest scores of BMD, being a finding consistent with a modest contribution of the miR (along with co-variables) to the mineralization of that site. Attesting clinical relevance of our findings demands forthcoming studies.
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spelling pubmed-71961512020-05-06 Circulating miR-34a and Bone Mineral Density of Brazilian Very-Old Adults Nóbrega, Otávio T. Morais-Junior, Gilberto S. Viana, Nayara I. Reis, Sabrina T. Perez, Diego I. V. Freitas, Wladimir M. Sposito, Andrei C. Leite, Kátia R. M. Srougi, Miguel J Aging Res Research Article The human aging is marked by several body changes, including in bone mineral density (BMD). Research shows that microRNAs are important modulators of bone metabolism. The present research aims to analyze the whole blood concentration of 10 selected microRNAs (miRs) and their association with absolute and relative scores of BMD in specific osseous site of Brazilian very-old adults. Forty noninstitutionalized and apparently healthy, very old (≥80 years) outpatients were eligible for research. Anthropometry, biochemistry, and densitometry measurements were performed along with coronary artery calcification (CAC) scores and tested across total circulating levels of microRNAs. As expected, the relative BMD scores for the lumbosacral region (L1 to S5) and for the femoral head and neck observed in the sample denote weakened bone architecture, compatible with prevalent osteopenia and osteoporosis. In this context, one single significant association was found, and negatively implicated the miR-34a-5p with both absolute (β = −0.36, P=0.001 for BMD) and relative (β = −0.43, P=0.001 for T-score) densitometry indexes of the femoral head (adjusted to sex and physical activity practice), but not with the other sites. No difference in total blood concentrations of the miRs was found according to CAC scores. Our findings indicate greater circulating levels for miR-34a-5p among very-old adults who display the lowest scores of BMD, being a finding consistent with a modest contribution of the miR (along with co-variables) to the mineralization of that site. Attesting clinical relevance of our findings demands forthcoming studies. Hindawi 2020-04-24 /pmc/articles/PMC7196151/ /pubmed/32377434 http://dx.doi.org/10.1155/2020/3431828 Text en Copyright © 2020 Otávio T. Nóbrega et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Nóbrega, Otávio T.
Morais-Junior, Gilberto S.
Viana, Nayara I.
Reis, Sabrina T.
Perez, Diego I. V.
Freitas, Wladimir M.
Sposito, Andrei C.
Leite, Kátia R. M.
Srougi, Miguel
Circulating miR-34a and Bone Mineral Density of Brazilian Very-Old Adults
title Circulating miR-34a and Bone Mineral Density of Brazilian Very-Old Adults
title_full Circulating miR-34a and Bone Mineral Density of Brazilian Very-Old Adults
title_fullStr Circulating miR-34a and Bone Mineral Density of Brazilian Very-Old Adults
title_full_unstemmed Circulating miR-34a and Bone Mineral Density of Brazilian Very-Old Adults
title_short Circulating miR-34a and Bone Mineral Density of Brazilian Very-Old Adults
title_sort circulating mir-34a and bone mineral density of brazilian very-old adults
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7196151/
https://www.ncbi.nlm.nih.gov/pubmed/32377434
http://dx.doi.org/10.1155/2020/3431828
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