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COVID-19: an update on diagnostic and therapeutic approaches

The unexpected pandemic set off by the novel coronavirus 2019 (COVID-19) has caused severe panic among people worldwide. COVID-19 has created havoc, and scientists and physicians are urged to test the efficiency and safety of drugs used to treat this disease. In such a pandemic situation, various st...

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Autores principales: Iyer, Mahalaxmi, Jayaramayya, Kaavya, Subramaniam, Mohana Devi, Lee, Soo Bin, Dayem, Ahmed Abdal, Cho, Ssang-Goo, Vellingiri, Balachandar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Biochemistry and Molecular Biology 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7196187/
https://www.ncbi.nlm.nih.gov/pubmed/32336317
http://dx.doi.org/10.5483/BMBRep.2020.53.4.080
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author Iyer, Mahalaxmi
Jayaramayya, Kaavya
Subramaniam, Mohana Devi
Lee, Soo Bin
Dayem, Ahmed Abdal
Cho, Ssang-Goo
Vellingiri, Balachandar
author_facet Iyer, Mahalaxmi
Jayaramayya, Kaavya
Subramaniam, Mohana Devi
Lee, Soo Bin
Dayem, Ahmed Abdal
Cho, Ssang-Goo
Vellingiri, Balachandar
author_sort Iyer, Mahalaxmi
collection PubMed
description The unexpected pandemic set off by the novel coronavirus 2019 (COVID-19) has caused severe panic among people worldwide. COVID-19 has created havoc, and scientists and physicians are urged to test the efficiency and safety of drugs used to treat this disease. In such a pandemic situation, various steps have been taken by the government to control and prevent the Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2). This pandemic situation has forced scientists to rework strategies to combat infectious diseases through drugs, treatment, and control measures. COVID-19 treatment requires both limiting viral multiplication and neutralizing tissue damage induced by an inappropriate immune reaction. Currently, various diagnostic kits to test for COVID-19 are available, and repurposing therapeutics for COVID-19 has shown to be clinically effective. As the global demand for diagnostics and therapeutics continues to rise, it is essential to rapidly develop various algorithms to successfully identify and contain the virus. This review discusses the updates on specimens/samples, recent efficient diagnostics, and therapeutic approaches to control the disease and repurposed drugs mainly focusing on chloroquine/hydroxychloroquine and convalescent plasma (CP). More research is required for further understanding of the influence of diagnostics and therapeutic approaches to develop vaccines and drugs for COVID-19.
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spelling pubmed-71961872020-05-13 COVID-19: an update on diagnostic and therapeutic approaches Iyer, Mahalaxmi Jayaramayya, Kaavya Subramaniam, Mohana Devi Lee, Soo Bin Dayem, Ahmed Abdal Cho, Ssang-Goo Vellingiri, Balachandar BMB Rep Invited Mini Review The unexpected pandemic set off by the novel coronavirus 2019 (COVID-19) has caused severe panic among people worldwide. COVID-19 has created havoc, and scientists and physicians are urged to test the efficiency and safety of drugs used to treat this disease. In such a pandemic situation, various steps have been taken by the government to control and prevent the Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2). This pandemic situation has forced scientists to rework strategies to combat infectious diseases through drugs, treatment, and control measures. COVID-19 treatment requires both limiting viral multiplication and neutralizing tissue damage induced by an inappropriate immune reaction. Currently, various diagnostic kits to test for COVID-19 are available, and repurposing therapeutics for COVID-19 has shown to be clinically effective. As the global demand for diagnostics and therapeutics continues to rise, it is essential to rapidly develop various algorithms to successfully identify and contain the virus. This review discusses the updates on specimens/samples, recent efficient diagnostics, and therapeutic approaches to control the disease and repurposed drugs mainly focusing on chloroquine/hydroxychloroquine and convalescent plasma (CP). More research is required for further understanding of the influence of diagnostics and therapeutic approaches to develop vaccines and drugs for COVID-19. Korean Society for Biochemistry and Molecular Biology 2020-04-30 2020-04-30 /pmc/articles/PMC7196187/ /pubmed/32336317 http://dx.doi.org/10.5483/BMBRep.2020.53.4.080 Text en Copyright © 2020 by the The Korean Society for Biochemistry and Molecular Biology This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Invited Mini Review
Iyer, Mahalaxmi
Jayaramayya, Kaavya
Subramaniam, Mohana Devi
Lee, Soo Bin
Dayem, Ahmed Abdal
Cho, Ssang-Goo
Vellingiri, Balachandar
COVID-19: an update on diagnostic and therapeutic approaches
title COVID-19: an update on diagnostic and therapeutic approaches
title_full COVID-19: an update on diagnostic and therapeutic approaches
title_fullStr COVID-19: an update on diagnostic and therapeutic approaches
title_full_unstemmed COVID-19: an update on diagnostic and therapeutic approaches
title_short COVID-19: an update on diagnostic and therapeutic approaches
title_sort covid-19: an update on diagnostic and therapeutic approaches
topic Invited Mini Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7196187/
https://www.ncbi.nlm.nih.gov/pubmed/32336317
http://dx.doi.org/10.5483/BMBRep.2020.53.4.080
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