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Prognostic value of stem cell markers in esophageal and esophagogastric junction cancer: a meta-analysis

Background: Esophageal cancer is an aggressive tumor, with poor prognosis and low survival rates. Although diagnosis and treatment have improved considerably, more efficient prognostic factors are urgently needed to prevent postoperative recurrence and metastasis. Cancer stem cells are key players i...

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Autores principales: Trevellin, Elisabetta, Pirozzolo, Giovanni, Fassan, Matteo, Vettor, Roberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7196270/
https://www.ncbi.nlm.nih.gov/pubmed/32368307
http://dx.doi.org/10.7150/jca.33699
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author Trevellin, Elisabetta
Pirozzolo, Giovanni
Fassan, Matteo
Vettor, Roberto
author_facet Trevellin, Elisabetta
Pirozzolo, Giovanni
Fassan, Matteo
Vettor, Roberto
author_sort Trevellin, Elisabetta
collection PubMed
description Background: Esophageal cancer is an aggressive tumor, with poor prognosis and low survival rates. Although diagnosis and treatment have improved considerably, more efficient prognostic factors are urgently needed to prevent postoperative recurrence and metastasis. Cancer stem cells are key players in tumor progression and several studies have investigated the association between the expression of stemness genes and clinical outcome. However, the prognostic value of stemness markers in esophageal cancer remains controversial. We identified six factors involved in angiogenesis, anti-apoptosis and self-renewal that have been associated to poor prognosis in other types of cancer. We conducted a review of the literature and a meta-analysis to assess their potential prognostic role in this malignancy. Material and Methods: The database of PMC, PubMed, Web of Science, Embase and The Cochrane Library were searched to investigate the association between CD34, CD133, Nucleostemin, OCT-4, NANOG and CD90, and the survival of patients affected by esophageal squamous cell carcinoma or esophageal adenocarcinoma. Among the 615 eligible studies, a total of 19 articles (including 1586 patients) met the inclusion criteria for the meta-analysis, and the pooled hazard ratio and 95% confidence intervals were calculated. Results: Data showed that high expression of CD34 (HR 2.10; 95%CI 1.41-3.14; I(2)=56%; p=0.0003), CD133 (HR 1.91; 95%CI 1.15-3.19; I(2)=55%; p=0.01) and Nucleostemin (HR 2.97; 95%CI 1.11-7.98; I(2)=0%; p=0.03) were associated with poor prognosis in patients affected by esophageal cancer. The expression of NANOG and OCT-4 showed no significant association with survival of patients, whereas no study involving CD90 was included in this meta-analysis. Conclusion: CD34, CD133 and Nucleostemin might represent useful prognostic markers in patients affected by esophageal cancer.
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spelling pubmed-71962702020-05-04 Prognostic value of stem cell markers in esophageal and esophagogastric junction cancer: a meta-analysis Trevellin, Elisabetta Pirozzolo, Giovanni Fassan, Matteo Vettor, Roberto J Cancer Research Paper Background: Esophageal cancer is an aggressive tumor, with poor prognosis and low survival rates. Although diagnosis and treatment have improved considerably, more efficient prognostic factors are urgently needed to prevent postoperative recurrence and metastasis. Cancer stem cells are key players in tumor progression and several studies have investigated the association between the expression of stemness genes and clinical outcome. However, the prognostic value of stemness markers in esophageal cancer remains controversial. We identified six factors involved in angiogenesis, anti-apoptosis and self-renewal that have been associated to poor prognosis in other types of cancer. We conducted a review of the literature and a meta-analysis to assess their potential prognostic role in this malignancy. Material and Methods: The database of PMC, PubMed, Web of Science, Embase and The Cochrane Library were searched to investigate the association between CD34, CD133, Nucleostemin, OCT-4, NANOG and CD90, and the survival of patients affected by esophageal squamous cell carcinoma or esophageal adenocarcinoma. Among the 615 eligible studies, a total of 19 articles (including 1586 patients) met the inclusion criteria for the meta-analysis, and the pooled hazard ratio and 95% confidence intervals were calculated. Results: Data showed that high expression of CD34 (HR 2.10; 95%CI 1.41-3.14; I(2)=56%; p=0.0003), CD133 (HR 1.91; 95%CI 1.15-3.19; I(2)=55%; p=0.01) and Nucleostemin (HR 2.97; 95%CI 1.11-7.98; I(2)=0%; p=0.03) were associated with poor prognosis in patients affected by esophageal cancer. The expression of NANOG and OCT-4 showed no significant association with survival of patients, whereas no study involving CD90 was included in this meta-analysis. Conclusion: CD34, CD133 and Nucleostemin might represent useful prognostic markers in patients affected by esophageal cancer. Ivyspring International Publisher 2020-04-27 /pmc/articles/PMC7196270/ /pubmed/32368307 http://dx.doi.org/10.7150/jca.33699 Text en © The author(s) This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Research Paper
Trevellin, Elisabetta
Pirozzolo, Giovanni
Fassan, Matteo
Vettor, Roberto
Prognostic value of stem cell markers in esophageal and esophagogastric junction cancer: a meta-analysis
title Prognostic value of stem cell markers in esophageal and esophagogastric junction cancer: a meta-analysis
title_full Prognostic value of stem cell markers in esophageal and esophagogastric junction cancer: a meta-analysis
title_fullStr Prognostic value of stem cell markers in esophageal and esophagogastric junction cancer: a meta-analysis
title_full_unstemmed Prognostic value of stem cell markers in esophageal and esophagogastric junction cancer: a meta-analysis
title_short Prognostic value of stem cell markers in esophageal and esophagogastric junction cancer: a meta-analysis
title_sort prognostic value of stem cell markers in esophageal and esophagogastric junction cancer: a meta-analysis
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7196270/
https://www.ncbi.nlm.nih.gov/pubmed/32368307
http://dx.doi.org/10.7150/jca.33699
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