Branched chain amino acids exacerbate myocardial ischemia/reperfusion vulnerability via enhancing GCN2/ATF6/PPAR-α pathway-dependent fatty acid oxidation

Rationale: Myocardial vulnerability to ischemia/reperfusion (I/R) injury is strictly regulated by energy substrate metabolism. Branched chain amino acids (BCAA), consisting of valine, leucine and isoleucine, are a group of essential amino acids that are highly oxidized in the heart. Elevated levels...

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Detalles Bibliográficos
Autores principales: Li, Yueyang, Xiong, Zhenyu, Yan, Wenjun, Gao, Erhe, Cheng, Hexiang, Wu, Guiling, Liu, Yi, Zhang, Ling, Li, Congye, Wang, Shan, Fan, Miaomiao, Zhao, Huishou, Zhang, Fuyang, Tao, Ling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7196282/
https://www.ncbi.nlm.nih.gov/pubmed/32373236
http://dx.doi.org/10.7150/thno.44836

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