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Graphene and other 2D materials: a multidisciplinary analysis to uncover the hidden potential as cancer theranostics

Cancer represents one of the main causes of death in the world; hence the development of more specific approaches for its diagnosis and treatment is urgently needed in clinical practice. Here we aim at providing a comprehensive review on the use of 2-dimensional materials (2DMs) in cancer theranosti...

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Autores principales: Fusco, Laura, Gazzi, Arianna, Peng, Guotao, Shin, Yuyoung, Vranic, Sandra, Bedognetti, Davide, Vitale, Flavia, Yilmazer, Acelya, Feng, Xinliang, Fadeel, Bengt, Casiraghi, Cinzia, Delogu, Lucia Gemma
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7196289/
https://www.ncbi.nlm.nih.gov/pubmed/32373222
http://dx.doi.org/10.7150/thno.40068
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author Fusco, Laura
Gazzi, Arianna
Peng, Guotao
Shin, Yuyoung
Vranic, Sandra
Bedognetti, Davide
Vitale, Flavia
Yilmazer, Acelya
Feng, Xinliang
Fadeel, Bengt
Casiraghi, Cinzia
Delogu, Lucia Gemma
author_facet Fusco, Laura
Gazzi, Arianna
Peng, Guotao
Shin, Yuyoung
Vranic, Sandra
Bedognetti, Davide
Vitale, Flavia
Yilmazer, Acelya
Feng, Xinliang
Fadeel, Bengt
Casiraghi, Cinzia
Delogu, Lucia Gemma
author_sort Fusco, Laura
collection PubMed
description Cancer represents one of the main causes of death in the world; hence the development of more specific approaches for its diagnosis and treatment is urgently needed in clinical practice. Here we aim at providing a comprehensive review on the use of 2-dimensional materials (2DMs) in cancer theranostics. In particular, we focus on graphene-related materials (GRMs), graphene hybrids, and graphdiyne (GDY), as well as other emerging 2DMs, such as MXene, tungsten disulfide (WS2), molybdenum disulfide (MoS2), hexagonal boron nitride (h-BN), black phosphorus (BP), silicene, antimonene (AM), germanene, biotite (black mica), metal organic frameworks (MOFs), and others. The results reported in the scientific literature in the last ten years (>200 papers) are dissected here with respect to the wide variety of combinations of imaging methodologies and therapeutic approaches, including drug/gene delivery, photothermal/photodynamic therapy, sonodynamic therapy, and immunotherapy. We provide a unique multidisciplinary approach in discussing the literature, which also includes a detailed section on the characterization methods used to analyze the material properties, highlighting the merits and limitations of the different approaches. The aim of this review is to show the strong potential of 2DMs for use as cancer theranostics, as well as to highlight issues that prevent the clinical translation of these materials. Overall, we hope to shed light on the hidden potential of the vast panorama of new and emerging 2DMs as clinical cancer theranostics.
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spelling pubmed-71962892020-05-05 Graphene and other 2D materials: a multidisciplinary analysis to uncover the hidden potential as cancer theranostics Fusco, Laura Gazzi, Arianna Peng, Guotao Shin, Yuyoung Vranic, Sandra Bedognetti, Davide Vitale, Flavia Yilmazer, Acelya Feng, Xinliang Fadeel, Bengt Casiraghi, Cinzia Delogu, Lucia Gemma Theranostics Review Cancer represents one of the main causes of death in the world; hence the development of more specific approaches for its diagnosis and treatment is urgently needed in clinical practice. Here we aim at providing a comprehensive review on the use of 2-dimensional materials (2DMs) in cancer theranostics. In particular, we focus on graphene-related materials (GRMs), graphene hybrids, and graphdiyne (GDY), as well as other emerging 2DMs, such as MXene, tungsten disulfide (WS2), molybdenum disulfide (MoS2), hexagonal boron nitride (h-BN), black phosphorus (BP), silicene, antimonene (AM), germanene, biotite (black mica), metal organic frameworks (MOFs), and others. The results reported in the scientific literature in the last ten years (>200 papers) are dissected here with respect to the wide variety of combinations of imaging methodologies and therapeutic approaches, including drug/gene delivery, photothermal/photodynamic therapy, sonodynamic therapy, and immunotherapy. We provide a unique multidisciplinary approach in discussing the literature, which also includes a detailed section on the characterization methods used to analyze the material properties, highlighting the merits and limitations of the different approaches. The aim of this review is to show the strong potential of 2DMs for use as cancer theranostics, as well as to highlight issues that prevent the clinical translation of these materials. Overall, we hope to shed light on the hidden potential of the vast panorama of new and emerging 2DMs as clinical cancer theranostics. Ivyspring International Publisher 2020-04-07 /pmc/articles/PMC7196289/ /pubmed/32373222 http://dx.doi.org/10.7150/thno.40068 Text en © The author(s) This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Review
Fusco, Laura
Gazzi, Arianna
Peng, Guotao
Shin, Yuyoung
Vranic, Sandra
Bedognetti, Davide
Vitale, Flavia
Yilmazer, Acelya
Feng, Xinliang
Fadeel, Bengt
Casiraghi, Cinzia
Delogu, Lucia Gemma
Graphene and other 2D materials: a multidisciplinary analysis to uncover the hidden potential as cancer theranostics
title Graphene and other 2D materials: a multidisciplinary analysis to uncover the hidden potential as cancer theranostics
title_full Graphene and other 2D materials: a multidisciplinary analysis to uncover the hidden potential as cancer theranostics
title_fullStr Graphene and other 2D materials: a multidisciplinary analysis to uncover the hidden potential as cancer theranostics
title_full_unstemmed Graphene and other 2D materials: a multidisciplinary analysis to uncover the hidden potential as cancer theranostics
title_short Graphene and other 2D materials: a multidisciplinary analysis to uncover the hidden potential as cancer theranostics
title_sort graphene and other 2d materials: a multidisciplinary analysis to uncover the hidden potential as cancer theranostics
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7196289/
https://www.ncbi.nlm.nih.gov/pubmed/32373222
http://dx.doi.org/10.7150/thno.40068
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