Cargando…

Cytochrome P450 enzyme-mediated auto-enhanced photodynamic cancer therapy of co-nanoassembly between clopidogrel and photosensitizer

Reactive oxygen species (ROS)-based photodynamic therapy (PDT) has a widespread application in cancer therapy. Nevertheless, the efficiency of PDT is far from satisfactory. One major impediment is the overexpression of glutathione (GSH) in tumor cells, which could deplete the level of PDT-generated...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Qiu, Sun, Mengchi, Li, Dan, Li, Chang, Luo, Cong, Wang, Zhaomeng, Zhang, Wenjuan, Yang, Zimeng, Feng, Yao, Wang, Shuang, He, Zhonggui, Zhang, Haotian, Kan, Qiming, Sun, Wei, Sun, Jin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2020
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7196307/ https://www.ncbi.nlm.nih.gov/pubmed/32373230 http://dx.doi.org/10.7150/thno.42633

Ejemplares similares

Photosensitizer-driven nanoassemblies of homodimeric prodrug for self-enhancing activation and synergistic chemo-photodynamic therapy
por: Zhang, Shenwu, et al.
Publicado: (2021)

Pure photosensitizer-driven nanoassembly with core-matched PEGylation for imaging-guided photodynamic therapy
por: Zhang, Shenwu, et al.
Publicado: (2021)

Probing the impact of sulfur/selenium/carbon linkages on prodrug nanoassemblies for cancer therapy
por: Sun, Bingjun, et al.
Publicado: (2019)

Structurally defined tandem-responsive nanoassemblies composed of dipeptide-based photosensitive derivatives and hypoxia-activated camptothecin prodrugs against primary and metastatic breast tumors
por: Sun, Mengchi, et al.
Publicado: (2022)

Self-delivering prodrug-nanoassemblies fabricated by disulfide bond bridged oleate prodrug of docetaxel for breast cancer therapy
por: Zhang, Shenwu, et al.
Publicado: (2017)

Erythrocyte membrane-camouflaged carrier-free nanoassembly of FRET photosensitizer pairs with high therapeutic efficiency and high security for programmed cancer synergistic phototherapy
por: Zhang, Xuanbo, et al.
Publicado: (2021)

Elaborately Engineering a Self‐Indicating Dual‐Drug Nanoassembly for Site‐Specific Photothermal‐Potentiated Thrombus Penetration and Thrombolysis
por: Zhao, Zhiqiang, et al.
Publicado: (2021)

Antimicrobial and Antibiofilm Photodynamic Action of Photosensitizing Nanoassemblies Based on Sulfobutylether-β-Cyclodextrin
por: Franco, Domenico, et al.
Publicado: (2023)

A computer-aided chem-photodynamic drugs self-delivery system for synergistically enhanced cancer therapy
por: Wang, Qiu, et al.
Publicado: (2021)

Hybrid chalcogen bonds in prodrug nanoassemblies provides dual redox-responsivity in the tumor microenvironment
por: Liu, Tian, et al.
Publicado: (2022)

Impact of the amount of PEG on prodrug nanoassemblies for efficient cancer therapy
por: Li, Yaqiao, et al.
Publicado: (2022)

Investigating the crucial roles of aliphatic tails in disulfide bond-linked docetaxel prodrug nanoassemblies
por: Wang, Yuequan, et al.
Publicado: (2021)

Association of Cytochrome P450 Genetic Variants with Clopidogrel Resistance and Outcomes in Acute Ischemic Stroke
por: Yi, Xingyang, et al.
Publicado: (2016)

Molecularly engineered carrier-free co-delivery nanoassembly for self-sensitized photothermal cancer therapy
por: Shan, Xinzhu, et al.
Publicado: (2021)

Spiropyran in nanoassemblies as a photosensitizer for photoswitchable ROS generation in living cells
por: Ji, Jinkai, et al.
Publicado: (2018)

Probing the fluorination effect on the self-assembly characteristics, in vivo fate and antitumor efficacy of paclitaxel prodrug nanoassemblies
por: Wang, Xin, et al.
Publicado: (2021)

Self-adaptive nanoassembly enabling turn-on hypoxia illumination and periphery/center closed-loop tumor eradication
por: Wang, Ziyue, et al.
Publicado: (2023)

Glutathione Pulse Therapy: Promote Spatiotemporal Delivery of Reduction‐Sensitive Nanoparticles at the “Cellular Level” and Synergize PD‐1 Blockade Therapy
por: Dong, Songtao, et al.
Publicado: (2022)

Disulfur-bridged polyethyleneglycol/DOX nanoparticles for the encapsulation of photosensitive drugs: a case of computational simulations on the redox-responsive chemo-photodynamic drug delivery system
por: Ma, Zhenchao, et al.
Publicado: (2021)

Co-amorphous solid dispersion systems of lacidipine-spironolactone with improved dissolution rate and enhanced physical stability
por: Wang, Zhaomeng, et al.
Publicado: (2019)

Photosensitive pro-drug nanoassemblies harboring a chemotherapeutic dormancy function potentiates cancer immunotherapy
por: Cheng, Jianjun, et al.
Publicado: (2023)

Succinic acid inhibits the activity of cytochrome P450 (CYP450) enzymes
por: Wang, Hao, et al.
Publicado: (2020)

Cytochrome P450 2C19 Polymorphism is Associated with Reduced Clopidogrel Response in Cerebrovascular Disease
por: Lee, Jun-Beom, et al.
Publicado: (2011)

Cytochrome P450 3A4*22, PPAR-α, and ARNT polymorphisms and clopidogrel response
por: Kreutz, Rolf P, et al.
Publicado: (2013)

Redox-sensitive prodrug nanoassemblies based on linoleic acid-modified docetaxel to resist breast cancers
por: Li, Meng, et al.
Publicado: (2019)

Small changes in the length of diselenide bond-containing linkages exert great influences on the antitumor activity of docetaxel homodimeric prodrug nanoassemblies
por: Li, Lingxiao, et al.
Publicado: (2021)

Clopidogrel preventive effect based on cytochrome P450 2C19 genotype in ischaemic stroke: protocol for multicentre observational study
por: Song, Tae-Jin, et al.
Publicado: (2020)

Hypoxia-activated NIR photosensitizer anchoring in the mitochondria for photodynamic therapy
por: Xu, Feng, et al.
Publicado: (2019)

Effects of Triflusal and Clopidogrel on the Secondary Prevention of Stroke Based on Cytochrome P450 2C19 Genotyping
por: Han, Sang Won, et al.
Publicado: (2017)

A Novel Photosensitizer for Lipid Droplet–Location Photodynamic Therapy
por: Xia, Xiang, et al.
Publicado: (2021)

Auto-Induction Effect of Chloroxoquinoline on the Cytochrome P450 Enzymes of Rats Associated with CYP 3A and 1A
por: Li, Xin, et al.
Publicado: (2015)

Molecularly engineering a dual-drug nanoassembly for self-sensitized photodynamic therapy via thioredoxin impairment and glutathione depletion
por: Zhang, Hongyuan, et al.
Publicado: (2022)

Association between cytochrome P450 2C19 polymorphism and clinical outcomes in clopidogrel-treated Uygur population with acute coronary syndrome: a retrospective study
por: Yu, Luhai, et al.
Publicado: (2021)

Trisulfide bond–mediated doxorubicin dimeric prodrug nanoassemblies with high drug loading, high self-assembly stability, and high tumor selectivity
por: Yang, Yinxian, et al.
Publicado: (2020)

Advances in photosensitizer-related design for photodynamic therapy
por: Zhou, Zhaojie, et al.
Publicado: (2021)

Influence of paraoxonase-1 Q192R and cytochrome P450 2C19 polymorphisms on clopidogrel response
por: Kreutz, Rolf P, et al.
Publicado: (2012)

Influence of cytochrome P450 polymorphisms on the antiplatelet effects of prasugrel in patients with non-cardioembolic stroke previously treated with clopidogrel
por: Kitazono, Takanari, et al.
Publicado: (2018)

An APN-activated NIR photosensitizer for cancer photodynamic therapy and fluorescence imaging
por: Zhou, Xiao, et al.
Publicado: (2020)

AIEE Active Nanoassemblies of Pyrazine Based Organic Photosensitizers as Efficient Metal-Free Supramolecular Photoredox Catalytic Systems
por: Dadwal, Shruti, et al.
Publicado: (2019)

Polydopamine-modified ROS-responsive prodrug nanoplatform with enhanced stability for precise treatment of breast cancer
por: Yang, Bin, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_ts48a4if1glfpg418lk3uuvper