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Characterization of IL-21-expressing recombinant hepatitis B virus (HBV) as a therapeutic agent targeting persisting HBV infection

Chronic infection by hepatitis B virus (HBV) is associated with high risks of liver fibrosis, cirrhosis and hepatocellular carcinoma. In mouse models of HBV persistence, interleukin 21 (IL-21) has been identified as a potent inducer of viral clearance. Strict hepatotropism makes recombinant HBV (rHB...

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Detalles Bibliográficos
Autores principales:	Shen, Zhongliang, Wu, Jingwen, Gao, Zixiang, Wang, Jingyu, Zhu, Haoxiang, Mao, Richen, Wang, Xuanyi, Zhang, Jiming, Xie, Youhua, Liu, Jing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2020
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7196313/ https://www.ncbi.nlm.nih.gov/pubmed/32373234 http://dx.doi.org/10.7150/thno.44715

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