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Association of ECE1 gene polymorphisms and essential hypertension risk in the Northern Han Chinese: A case‒control study

BACKGROUND: The ECE1 gene polymorphisms have been studied as a candidate gene in essential hypertension, but no consensus has been reached. To systematically explore their possible association, a case‒control study was conducted. METHODS: This study included 398 hypertensive subjects and 596 healthy...

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Autores principales: Wang, Hao, Liu, Jielin, Liu, Kuo, Liu, Ya, Wen, Jie, Wang, Zuoguang, Wen, Shaojun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7196447/
https://www.ncbi.nlm.nih.gov/pubmed/32107880
http://dx.doi.org/10.1002/mgg3.1188
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author Wang, Hao
Liu, Jielin
Liu, Kuo
Liu, Ya
Wen, Jie
Wang, Zuoguang
Wen, Shaojun
author_facet Wang, Hao
Liu, Jielin
Liu, Kuo
Liu, Ya
Wen, Jie
Wang, Zuoguang
Wen, Shaojun
author_sort Wang, Hao
collection PubMed
description BACKGROUND: The ECE1 gene polymorphisms have been studied as a candidate gene in essential hypertension, but no consensus has been reached. To systematically explore their possible association, a case‒control study was conducted. METHODS: This study included 398 hypertensive subjects and 596 healthy volunteers as control subjects in the Northern Han Chinese. A total of 10 tag SNPs of ECE1 gene were genotyped successfully by TaqMan assay. RESULTS: A total of 10 SNPs (rs212544, rs2076280, rs115071, rs2076283, rs9426748, rs11590928, rs212515, rs2236847, rs2282715, and rs2774028) were identified as the tag SNPs for ECE1 gene. Although no positive connection has been found in general population, several SNPs have been found to be related to EH risk in gender‐stratified subgroup analysis. In males, rs115071 T allele influenced EH risk in a protective manner, with dominant model (TT+TC vs. CC: p = .032, OR = 0.655, 95% CI = 0.445–0.965), additive model (TT vs. TC vs. CC: p = .019, OR = 0.616, 95% CI = 0.411–0.924), as well as allele comparison (T vs. C: p = .045, OR = 0.702, 95% CI = 0.496–0.992). While, in females, rs212544 AA genotype would increase the onset risk of EH (recessive model: AA vs. GA+GG, p = .024, OR = 1.847, 95% CI = 1.086–3.142). In the three haplotype blocks identified, rs2076283‐rs2236847 C‐T haplotype was associated with a decreased risk of EH (OR = 0.558, p = .046). CONCLUSION: The current case‒control study suggested that several SNPs and related haplotypes on ECE1 gene might be associated with the susceptibility of EH in certain gender subgroups in the Northern Han Chinese population.
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spelling pubmed-71964472020-05-04 Association of ECE1 gene polymorphisms and essential hypertension risk in the Northern Han Chinese: A case‒control study Wang, Hao Liu, Jielin Liu, Kuo Liu, Ya Wen, Jie Wang, Zuoguang Wen, Shaojun Mol Genet Genomic Med Original Articles BACKGROUND: The ECE1 gene polymorphisms have been studied as a candidate gene in essential hypertension, but no consensus has been reached. To systematically explore their possible association, a case‒control study was conducted. METHODS: This study included 398 hypertensive subjects and 596 healthy volunteers as control subjects in the Northern Han Chinese. A total of 10 tag SNPs of ECE1 gene were genotyped successfully by TaqMan assay. RESULTS: A total of 10 SNPs (rs212544, rs2076280, rs115071, rs2076283, rs9426748, rs11590928, rs212515, rs2236847, rs2282715, and rs2774028) were identified as the tag SNPs for ECE1 gene. Although no positive connection has been found in general population, several SNPs have been found to be related to EH risk in gender‐stratified subgroup analysis. In males, rs115071 T allele influenced EH risk in a protective manner, with dominant model (TT+TC vs. CC: p = .032, OR = 0.655, 95% CI = 0.445–0.965), additive model (TT vs. TC vs. CC: p = .019, OR = 0.616, 95% CI = 0.411–0.924), as well as allele comparison (T vs. C: p = .045, OR = 0.702, 95% CI = 0.496–0.992). While, in females, rs212544 AA genotype would increase the onset risk of EH (recessive model: AA vs. GA+GG, p = .024, OR = 1.847, 95% CI = 1.086–3.142). In the three haplotype blocks identified, rs2076283‐rs2236847 C‐T haplotype was associated with a decreased risk of EH (OR = 0.558, p = .046). CONCLUSION: The current case‒control study suggested that several SNPs and related haplotypes on ECE1 gene might be associated with the susceptibility of EH in certain gender subgroups in the Northern Han Chinese population. John Wiley and Sons Inc. 2020-02-27 /pmc/articles/PMC7196447/ /pubmed/32107880 http://dx.doi.org/10.1002/mgg3.1188 Text en © 2020 The Authors. Molecular Genetics & Genomic Medicine published by Wiley Periodicals, Inc. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Wang, Hao
Liu, Jielin
Liu, Kuo
Liu, Ya
Wen, Jie
Wang, Zuoguang
Wen, Shaojun
Association of ECE1 gene polymorphisms and essential hypertension risk in the Northern Han Chinese: A case‒control study
title Association of ECE1 gene polymorphisms and essential hypertension risk in the Northern Han Chinese: A case‒control study
title_full Association of ECE1 gene polymorphisms and essential hypertension risk in the Northern Han Chinese: A case‒control study
title_fullStr Association of ECE1 gene polymorphisms and essential hypertension risk in the Northern Han Chinese: A case‒control study
title_full_unstemmed Association of ECE1 gene polymorphisms and essential hypertension risk in the Northern Han Chinese: A case‒control study
title_short Association of ECE1 gene polymorphisms and essential hypertension risk in the Northern Han Chinese: A case‒control study
title_sort association of ece1 gene polymorphisms and essential hypertension risk in the northern han chinese: a case‒control study
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7196447/
https://www.ncbi.nlm.nih.gov/pubmed/32107880
http://dx.doi.org/10.1002/mgg3.1188
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