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Genetic diversity and phylogenetic structure of four Tibeto‐Burman‐speaking populations in Tibetan‐Yi corridor revealed by insertion/deletion polymorphisms

BACKGROUND: Insertion/deletion polymorphisms (InDels), combined with all the desirable features of both short tandem repeat and single nucleotide polymorphism, have been used in archaeological and anthropological research, population genetics and forensic application. METHODS: Thirty InDels in 530 i...

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Autores principales: Zou, Xing, He, Guanglin, Wang, Mengge, Huo, Liwen, Chen, Xu, Liu, Jing, Wang, Shouyu, Ye, Ziwei, Wang, Fei, Wang, Zheng, Hou, Yiping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7196475/
https://www.ncbi.nlm.nih.gov/pubmed/32017463
http://dx.doi.org/10.1002/mgg3.1140
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author Zou, Xing
He, Guanglin
Wang, Mengge
Huo, Liwen
Chen, Xu
Liu, Jing
Wang, Shouyu
Ye, Ziwei
Wang, Fei
Wang, Zheng
Hou, Yiping
author_facet Zou, Xing
He, Guanglin
Wang, Mengge
Huo, Liwen
Chen, Xu
Liu, Jing
Wang, Shouyu
Ye, Ziwei
Wang, Fei
Wang, Zheng
Hou, Yiping
author_sort Zou, Xing
collection PubMed
description BACKGROUND: Insertion/deletion polymorphisms (InDels), combined with all the desirable features of both short tandem repeat and single nucleotide polymorphism, have been used in archaeological and anthropological research, population genetics and forensic application. METHODS: Thirty InDels in 530 individuals residing in the Tibetan‐Yi corridor (142 Dujiangyan Tibetans, 164 Muli Tibetans, 187 Xichang Yis, and 37 Yanyuan Mosuos) were genotyped using the Investigator DIPplex. Forensic parameters and allele frequency spectrum were calculated. Genetic relationships between the investigated populations and worldwide and nationwide populations were assessed based on both the allele frequency distribution and genotype data. RESULTS: The combined powers of exclusion were 0.9807 (Dujiangyan Tibetan), 0.9880 (Muli Tibetan), 0.9852 (Xichang Yi) and 0.9892 (Yanyuan Mosuo). The combined powers of discrimination were 0.999999999983 (Dujiangyan Tibetan), 0.999999999942 (Muli Tibetan), 0.999999999982 (Xichang Yi) and 0.999999999962 (Yanyuan Mosuo), respectively. The comprehensive population comparisons among worldwide and nationwide populations uniformly illustrated that the investigated populations have a genetically closer relationship with Tibeto‐Burman‐speaking populations and geographically adjacent populations. CONCLUSION: These 30 loci can be regarded as an efficient genetic tool in forensic individual identification and as a supplementary tool in paternity testing in Dujiangyan Tibetan, Muli Tibetan, Xichang Yi, and Yanyuan Mosuo. The genetic proximity between the four populations in the Tibetan‐Yi corridor and other populations is strongly correlated with the linguistic origin and geographical distance.
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spelling pubmed-71964752020-05-04 Genetic diversity and phylogenetic structure of four Tibeto‐Burman‐speaking populations in Tibetan‐Yi corridor revealed by insertion/deletion polymorphisms Zou, Xing He, Guanglin Wang, Mengge Huo, Liwen Chen, Xu Liu, Jing Wang, Shouyu Ye, Ziwei Wang, Fei Wang, Zheng Hou, Yiping Mol Genet Genomic Med Original Articles BACKGROUND: Insertion/deletion polymorphisms (InDels), combined with all the desirable features of both short tandem repeat and single nucleotide polymorphism, have been used in archaeological and anthropological research, population genetics and forensic application. METHODS: Thirty InDels in 530 individuals residing in the Tibetan‐Yi corridor (142 Dujiangyan Tibetans, 164 Muli Tibetans, 187 Xichang Yis, and 37 Yanyuan Mosuos) were genotyped using the Investigator DIPplex. Forensic parameters and allele frequency spectrum were calculated. Genetic relationships between the investigated populations and worldwide and nationwide populations were assessed based on both the allele frequency distribution and genotype data. RESULTS: The combined powers of exclusion were 0.9807 (Dujiangyan Tibetan), 0.9880 (Muli Tibetan), 0.9852 (Xichang Yi) and 0.9892 (Yanyuan Mosuo). The combined powers of discrimination were 0.999999999983 (Dujiangyan Tibetan), 0.999999999942 (Muli Tibetan), 0.999999999982 (Xichang Yi) and 0.999999999962 (Yanyuan Mosuo), respectively. The comprehensive population comparisons among worldwide and nationwide populations uniformly illustrated that the investigated populations have a genetically closer relationship with Tibeto‐Burman‐speaking populations and geographically adjacent populations. CONCLUSION: These 30 loci can be regarded as an efficient genetic tool in forensic individual identification and as a supplementary tool in paternity testing in Dujiangyan Tibetan, Muli Tibetan, Xichang Yi, and Yanyuan Mosuo. The genetic proximity between the four populations in the Tibetan‐Yi corridor and other populations is strongly correlated with the linguistic origin and geographical distance. John Wiley and Sons Inc. 2020-02-03 /pmc/articles/PMC7196475/ /pubmed/32017463 http://dx.doi.org/10.1002/mgg3.1140 Text en © 2020 The Authors. Molecular Genetics & Genomic Medicine published by Wiley Periodicals, Inc. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Zou, Xing
He, Guanglin
Wang, Mengge
Huo, Liwen
Chen, Xu
Liu, Jing
Wang, Shouyu
Ye, Ziwei
Wang, Fei
Wang, Zheng
Hou, Yiping
Genetic diversity and phylogenetic structure of four Tibeto‐Burman‐speaking populations in Tibetan‐Yi corridor revealed by insertion/deletion polymorphisms
title Genetic diversity and phylogenetic structure of four Tibeto‐Burman‐speaking populations in Tibetan‐Yi corridor revealed by insertion/deletion polymorphisms
title_full Genetic diversity and phylogenetic structure of four Tibeto‐Burman‐speaking populations in Tibetan‐Yi corridor revealed by insertion/deletion polymorphisms
title_fullStr Genetic diversity and phylogenetic structure of four Tibeto‐Burman‐speaking populations in Tibetan‐Yi corridor revealed by insertion/deletion polymorphisms
title_full_unstemmed Genetic diversity and phylogenetic structure of four Tibeto‐Burman‐speaking populations in Tibetan‐Yi corridor revealed by insertion/deletion polymorphisms
title_short Genetic diversity and phylogenetic structure of four Tibeto‐Burman‐speaking populations in Tibetan‐Yi corridor revealed by insertion/deletion polymorphisms
title_sort genetic diversity and phylogenetic structure of four tibeto‐burman‐speaking populations in tibetan‐yi corridor revealed by insertion/deletion polymorphisms
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7196475/
https://www.ncbi.nlm.nih.gov/pubmed/32017463
http://dx.doi.org/10.1002/mgg3.1140
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