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Demographic and Psychosocial factors associated with Hair Cortisol Concentrations in Preschool Children

BACKGROUND: Early life stress has enduring effects on physical and mental health. Hair cortisol concentrations (HCC) reflect exposures to contextual stressors in early life, but are understudied in preschool children. METHODS: Hair samples from children (N=693) during clinic visits (CV) scheduled at...

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Autores principales: Anand, Kanwaljeet J. S., Rovnaghi, Cynthia R., Rigdon, Joseph, Qin, FeiFei, Tembulkar, Sahil, Murphy, Laura E., Barr, Donald A., Gotlib, Ian H., Tylavsky, Frances A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7196501/
https://www.ncbi.nlm.nih.gov/pubmed/31791042
http://dx.doi.org/10.1038/s41390-019-0691-2
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author Anand, Kanwaljeet J. S.
Rovnaghi, Cynthia R.
Rigdon, Joseph
Qin, FeiFei
Tembulkar, Sahil
Murphy, Laura E.
Barr, Donald A.
Gotlib, Ian H.
Tylavsky, Frances A.
author_facet Anand, Kanwaljeet J. S.
Rovnaghi, Cynthia R.
Rigdon, Joseph
Qin, FeiFei
Tembulkar, Sahil
Murphy, Laura E.
Barr, Donald A.
Gotlib, Ian H.
Tylavsky, Frances A.
author_sort Anand, Kanwaljeet J. S.
collection PubMed
description BACKGROUND: Early life stress has enduring effects on physical and mental health. Hair cortisol concentrations (HCC) reflect exposures to contextual stressors in early life, but are understudied in preschool children. METHODS: Hair samples from children (N=693) during clinic visits (CV) scheduled at 1–4 years (CV1-CV4) were measured using validated assay methods for HCC. RESULTS: HCC were highest at CV1 and decreased at CV2-CV4, with no sex differences. Black children had higher HCC than White/other children; these differences persisted even after adjusting for socioeconomic factors. Bivariable analyses showed significant effects on HCC for Black race, with specific demographic and psychosocial factors at different ages. Multivariable analyses showed that higher HCC at CV1 were associated with Black race and male sex; at CV2 with Black race, lower maternal self-esteem, socioeconomic adversity, and the child’s risk for developmental delay; at CV3 with Black race; at CV4 with maternal depression and the child’s prior HCC values. CONCLUSIONS: HCC were higher in Black children than White/other races; differences were related to maternal factors, socioeconomic adversity, and the child’s risk for developmental delay. Public health measures to reduce disparities between Blacks and other races must also consider the long-term effects of chronic stress in early life.
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spelling pubmed-71965012020-06-02 Demographic and Psychosocial factors associated with Hair Cortisol Concentrations in Preschool Children Anand, Kanwaljeet J. S. Rovnaghi, Cynthia R. Rigdon, Joseph Qin, FeiFei Tembulkar, Sahil Murphy, Laura E. Barr, Donald A. Gotlib, Ian H. Tylavsky, Frances A. Pediatr Res Article BACKGROUND: Early life stress has enduring effects on physical and mental health. Hair cortisol concentrations (HCC) reflect exposures to contextual stressors in early life, but are understudied in preschool children. METHODS: Hair samples from children (N=693) during clinic visits (CV) scheduled at 1–4 years (CV1-CV4) were measured using validated assay methods for HCC. RESULTS: HCC were highest at CV1 and decreased at CV2-CV4, with no sex differences. Black children had higher HCC than White/other children; these differences persisted even after adjusting for socioeconomic factors. Bivariable analyses showed significant effects on HCC for Black race, with specific demographic and psychosocial factors at different ages. Multivariable analyses showed that higher HCC at CV1 were associated with Black race and male sex; at CV2 with Black race, lower maternal self-esteem, socioeconomic adversity, and the child’s risk for developmental delay; at CV3 with Black race; at CV4 with maternal depression and the child’s prior HCC values. CONCLUSIONS: HCC were higher in Black children than White/other races; differences were related to maternal factors, socioeconomic adversity, and the child’s risk for developmental delay. Public health measures to reduce disparities between Blacks and other races must also consider the long-term effects of chronic stress in early life. 2019-12-02 2020-05 /pmc/articles/PMC7196501/ /pubmed/31791042 http://dx.doi.org/10.1038/s41390-019-0691-2 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Anand, Kanwaljeet J. S.
Rovnaghi, Cynthia R.
Rigdon, Joseph
Qin, FeiFei
Tembulkar, Sahil
Murphy, Laura E.
Barr, Donald A.
Gotlib, Ian H.
Tylavsky, Frances A.
Demographic and Psychosocial factors associated with Hair Cortisol Concentrations in Preschool Children
title Demographic and Psychosocial factors associated with Hair Cortisol Concentrations in Preschool Children
title_full Demographic and Psychosocial factors associated with Hair Cortisol Concentrations in Preschool Children
title_fullStr Demographic and Psychosocial factors associated with Hair Cortisol Concentrations in Preschool Children
title_full_unstemmed Demographic and Psychosocial factors associated with Hair Cortisol Concentrations in Preschool Children
title_short Demographic and Psychosocial factors associated with Hair Cortisol Concentrations in Preschool Children
title_sort demographic and psychosocial factors associated with hair cortisol concentrations in preschool children
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7196501/
https://www.ncbi.nlm.nih.gov/pubmed/31791042
http://dx.doi.org/10.1038/s41390-019-0691-2
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