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(123)I-FP-CIT SPECT validation of nigro-putaminal MRI tractography in dementia with Lewy bodies
BACKGROUND: Assessment of nigrostriatal degeneration is a key element to discriminate between dementia with Lewy bodies (DLB) and Alzheimer disease (AD), and it is often evaluated using ioflupane ((123)I-FP-CIT) single-photon emission computed tomography (SPECT). Given the limited availability of (1...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7196565/ https://www.ncbi.nlm.nih.gov/pubmed/32363488 http://dx.doi.org/10.1186/s41747-020-00153-6 |
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author | Pardini, Matteo Nobili, Flavio Arnaldi, Dario Morbelli, Silvia Bauckneht, Matteo Rissotto, Roberto Serrati, Carlo Serafini, Gianluca Lapucci, Caterina Ghio, Lucio Amore, Mario Massucco, Davide Sassos, Davide Bonzano, Laura Mancardi, Giovanni Luigi Roccatagliata, Luca |
author_facet | Pardini, Matteo Nobili, Flavio Arnaldi, Dario Morbelli, Silvia Bauckneht, Matteo Rissotto, Roberto Serrati, Carlo Serafini, Gianluca Lapucci, Caterina Ghio, Lucio Amore, Mario Massucco, Davide Sassos, Davide Bonzano, Laura Mancardi, Giovanni Luigi Roccatagliata, Luca |
author_sort | Pardini, Matteo |
collection | PubMed |
description | BACKGROUND: Assessment of nigrostriatal degeneration is a key element to discriminate between dementia with Lewy bodies (DLB) and Alzheimer disease (AD), and it is often evaluated using ioflupane ((123)I-FP-CIT) single-photon emission computed tomography (SPECT). Given the limited availability of (123)I-FP-CIT SPECT, we evaluated if a mask-based approach to nigroputaminal magnetic resonance imaging (MRI) diffusion-weighted tractography could be able to capture microstructural changes reflecting nigroputaminal degeneration in DLB. METHODS: A nigroputaminal bundle mask was delineated on 12 healthy volunteers (HV) and applied to MRI diffusion-weighted data of 18 subjects with DLB, 21 subjects with AD and another group of 12 HV. The correlation between nigroputaminal fractional anisotropy (FA) values and (123)I-FP-CIT SPECT findings was investigated. Shapiro-Wilk, ANOVA, ANCOVA, and parametric correlation statistics as well as receiver operating characteristic (ROC) analysis were used. RESULTS: DLB patients showed a higher nigroputaminal FA values compared with both AD and HV-controls groups (p = 0.001 for both comparisons), while no difference was observed between HV-controls and AD groups (p = 0.450); at ROC analysis, the area under the curve for the discriminating DLB and AD subjects was 0.820; FA values correlated with (123)I-FP-CIT values (on the left, r = -0.670; on the right, r = -720). No significant differences were observed for the FA of the corticospinal tract across the three groups (p = 0.740). CONCLUSIONS: In DLB, nigroputaminal degeneration could be reliably assessed on MRI diffusion scans using a mask of nigroputaminal bundle trajectory. Nigroputaminal FA in DLB patients correlated with (123)I-FP-CIT values data may allow to differentiate these patients from AD patients and HV-controls. |
format | Online Article Text |
id | pubmed-7196565 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-71965652020-05-06 (123)I-FP-CIT SPECT validation of nigro-putaminal MRI tractography in dementia with Lewy bodies Pardini, Matteo Nobili, Flavio Arnaldi, Dario Morbelli, Silvia Bauckneht, Matteo Rissotto, Roberto Serrati, Carlo Serafini, Gianluca Lapucci, Caterina Ghio, Lucio Amore, Mario Massucco, Davide Sassos, Davide Bonzano, Laura Mancardi, Giovanni Luigi Roccatagliata, Luca Eur Radiol Exp Original Article BACKGROUND: Assessment of nigrostriatal degeneration is a key element to discriminate between dementia with Lewy bodies (DLB) and Alzheimer disease (AD), and it is often evaluated using ioflupane ((123)I-FP-CIT) single-photon emission computed tomography (SPECT). Given the limited availability of (123)I-FP-CIT SPECT, we evaluated if a mask-based approach to nigroputaminal magnetic resonance imaging (MRI) diffusion-weighted tractography could be able to capture microstructural changes reflecting nigroputaminal degeneration in DLB. METHODS: A nigroputaminal bundle mask was delineated on 12 healthy volunteers (HV) and applied to MRI diffusion-weighted data of 18 subjects with DLB, 21 subjects with AD and another group of 12 HV. The correlation between nigroputaminal fractional anisotropy (FA) values and (123)I-FP-CIT SPECT findings was investigated. Shapiro-Wilk, ANOVA, ANCOVA, and parametric correlation statistics as well as receiver operating characteristic (ROC) analysis were used. RESULTS: DLB patients showed a higher nigroputaminal FA values compared with both AD and HV-controls groups (p = 0.001 for both comparisons), while no difference was observed between HV-controls and AD groups (p = 0.450); at ROC analysis, the area under the curve for the discriminating DLB and AD subjects was 0.820; FA values correlated with (123)I-FP-CIT values (on the left, r = -0.670; on the right, r = -720). No significant differences were observed for the FA of the corticospinal tract across the three groups (p = 0.740). CONCLUSIONS: In DLB, nigroputaminal degeneration could be reliably assessed on MRI diffusion scans using a mask of nigroputaminal bundle trajectory. Nigroputaminal FA in DLB patients correlated with (123)I-FP-CIT values data may allow to differentiate these patients from AD patients and HV-controls. Springer International Publishing 2020-05-04 /pmc/articles/PMC7196565/ /pubmed/32363488 http://dx.doi.org/10.1186/s41747-020-00153-6 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Original Article Pardini, Matteo Nobili, Flavio Arnaldi, Dario Morbelli, Silvia Bauckneht, Matteo Rissotto, Roberto Serrati, Carlo Serafini, Gianluca Lapucci, Caterina Ghio, Lucio Amore, Mario Massucco, Davide Sassos, Davide Bonzano, Laura Mancardi, Giovanni Luigi Roccatagliata, Luca (123)I-FP-CIT SPECT validation of nigro-putaminal MRI tractography in dementia with Lewy bodies |
title | (123)I-FP-CIT SPECT validation of nigro-putaminal MRI tractography in dementia with Lewy bodies |
title_full | (123)I-FP-CIT SPECT validation of nigro-putaminal MRI tractography in dementia with Lewy bodies |
title_fullStr | (123)I-FP-CIT SPECT validation of nigro-putaminal MRI tractography in dementia with Lewy bodies |
title_full_unstemmed | (123)I-FP-CIT SPECT validation of nigro-putaminal MRI tractography in dementia with Lewy bodies |
title_short | (123)I-FP-CIT SPECT validation of nigro-putaminal MRI tractography in dementia with Lewy bodies |
title_sort | (123)i-fp-cit spect validation of nigro-putaminal mri tractography in dementia with lewy bodies |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7196565/ https://www.ncbi.nlm.nih.gov/pubmed/32363488 http://dx.doi.org/10.1186/s41747-020-00153-6 |
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