Cargando…

EGFR‐targeted CAR‐T cells are potent and specific in suppressing triple‐negative breast cancer both in vitro and in vivo

OBJECTIVES: Triple‐negative breast cancer (TNBC) is well known for its strong invasiveness, rapid recurrence and poor prognosis. Immunotherapy, including chimeric antigen receptor‐modified T (CAR‐T) cells, has emerged as a promising tool to treat TNBC. The identification of a specific target tumor a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xia, Lin, Zheng, Zao‐zao, Liu, Jun‐yi, Chen, Yu‐jie, Ding, Jian‐cheng, Xia, Ning‐shao, Luo, Wen‐xin, Liu, Wen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2020
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7196685/ https://www.ncbi.nlm.nih.gov/pubmed/32373345 http://dx.doi.org/10.1002/cti2.1135

Ejemplares similares

BRD4 inhibition boosts the therapeutic effects of epidermal growth factor receptor-targeted chimeric antigen receptor T cells in glioblastoma
por: Xia, Lin, et al.
Publicado: (2021)

A specific JMJD6 inhibitor potently suppresses multiple types of cancers both in vitro and in vivo
por: Xiao, Rong-quan, et al.
Publicado: (2022)

A SARS-CoV-2-specific CAR-T-cell model identifies felodipine, fasudil, imatinib, and caspofungin as potential treatments for lethal COVID-19
por: Xia, Lin, et al.
Publicado: (2023)

Idiopathic Macular Hole: A Comprehensive Review of Its Pathogenesis and of Advanced Studies on Metamorphopsia
por: Chen, Qi, et al.
Publicado: (2019)

Discovery of HCD3514 as a potent EGFR inhibitor against C797S mutation in vitro and in vivo
por: Lai, Mengzhen, et al.
Publicado: (2023)

Minicircle DNA-Mediated CAR T Cells Targeting CD44 Suppressed Hepatocellular Carcinoma Both in vitro and in vivo
por: Wang, Hezhi, et al.
Publicado: (2020)

Methionine deprivation suppresses triple-negative breast cancer metastasis in vitro and in vivo
por: Jeon, Hyein, et al.
Publicado: (2016)

Minicircle DNA-Mediated CAR T Cells Targeting CD44 Suppressed Hepatocellular Carcinoma Both in vitro and in vivo [Corrigendum]
Publicado: (2020)

Pharmacological activation of FOXO3 suppresses triple-negative breast cancer in vitro and in vivo
por: Park, See-Hyoung, et al.
Publicado: (2016)

Super-enhancer-controlled positive feedback loop BRD4/ERα–RET–ERα promotes ERα-positive breast cancer
por: Zheng, Zao-zao, et al.
Publicado: (2022)

Folate Receptor-Alpha Targeted 7x19 CAR-γδT Suppressed Triple-Negative Breast Cancer Xenograft Model in Mice
por: Ye, Xueshuai, et al.
Publicado: (2022)

Nucleus-enriched Ruthenium Polypyridine Complex Acts as a Potent Inhibitor to Suppress Triple-negative Breast Cancer Metastasis In vivo
por: Zhao, Xuanhao, et al.
Publicado: (2018)

Picropodophyllin (PPP) is a potent rhabdomyosarcoma growth inhibitor both in vitro and in vivo
por: Tarnowski, Maciej, et al.
Publicado: (2017)

ASK120067 potently suppresses B-cell or T-cell malignancies in vitro and in vivo by inhibiting BTK and ITK
por: Song, Peiran, et al.
Publicado: (2022)

CAR-T cells targeting HLA-G as potent therapeutic strategy for EGFR-mutated and overexpressed oral cancer
por: Lin, Yu-Chuan, et al.
Publicado: (2023)

Application of functional quantum dot nanoparticles as fluorescence probes in cell labeling and tumor diagnostic imaging
por: Zhao, Mei-Xia, et al.
Publicado: (2015)

LS‐106, a novel EGFR inhibitor targeting C797S, exhibits antitumor activities both in vitro and in vivo
por: Liu, Yingqiang, et al.
Publicado: (2021)

Targeting EGFR in Triple Negative Breast Cancer
por: Ueno, Naoto T., et al.
Publicado: (2011)

Anti-EGFR anchored paclitaxel loaded PLGA nanoparticles for the treatment of triple negative breast cancer. In-vitro and in-vivo anticancer activities
por: Venugopal, Vijayan, et al.
Publicado: (2018)

Triple-Band Surface Plasmon Resonance Metamaterial Absorber Based on Open-Ended Prohibited Sign Type Monolayer Graphene
por: Lai, Runing, et al.
Publicado: (2023)

Combined inhibition of EGFR and c-ABL suppresses the growth of triple-negative breast cancer growth through inhibition of HOTAIR
por: Wang, Yuan-Liang, et al.
Publicado: (2015)

The spatial effects of rural toilet retrofitting investment on farmers' medical and health expenditure in China
por: Zheng, Xin, et al.
Publicado: (2023)

Suppressing Src-Mediated EGFR Signaling by Sustained Calcium Supply Targeting Triple-Negative Breast Cancer
por: Jeong, Keun-Yeong, et al.
Publicado: (2023)

High copy number variations, particular transcription factors, and low immunity contribute to the stemness of prostate cancer cells
por: Dai, Zao, et al.
Publicado: (2021)

Qualitative theory of differential equations
por: Zhang, Zhifeng, et al.
Publicado: (1992)

Targeting the EGFR/PCNA Signaling Suppresses Tumor Growth of Triple-Negative Breast Cancer Cells with Cell-Penetrating PCNA Peptides
por: Yu, Yung-Luen, et al.
Publicado: (2013)

Triple negative breast carcinoma EGFR amplification is not associated with EGFR, Kras or ALK mutations
por: Secq, V, et al.
Publicado: (2014)

EGFR inhibition blocks cancer stem cell clustering and lung metastasis of triple negative breast cancer
por: Liu, Xia, et al.
Publicado: (2021)

Exosomes-Coated miR-34a Displays Potent Antitumor Activity in Pancreatic Cancer Both in vitro and in vivo
por: Zuo, Ling, et al.
Publicado: (2020)

Lack of epidermal growth factor receptor (EGFR)-activating mutations in triple-negative breast cancer in China
por: Cao, Wen-Ming, et al.
Publicado: (2015)

Nanobiopolymer for Direct Targeting and Inhibition of EGFR Expression in Triple Negative Breast Cancer
por: Inoue, Satoshi, et al.
Publicado: (2012)

Synergistic action by multi-targeting compounds produces a potent compound combination for human NSCLC both in vitro and in vivo
por: Zhang, C, et al.
Publicado: (2014)

Anti‐EGFR antibody‐drug conjugate for triple‐negative breast cancer therapy
por: Si, Yingnan, et al.
Publicado: (2020)

CAR-T cell therapy in triple-negative breast cancer: Hunting the invisible devil
por: Nasiri, Fatemeh, et al.
Publicado: (2022)

EGFR expression is associated with cytoplasmic staining of CXCR4 and predicts poor prognosis in triple-negative breast carcinomas
por: Li, Rong-Hui, et al.
Publicado: (2017)

Control of triple-negative breast cancer using ex vivo self-enriched, costimulated NKG2D CAR T cells
por: Han, Yali, et al.
Publicado: (2018)

In vitro antineoplastic activity in triple-negative breast cancer cell line and in vivo
por: Madeira, Klesia, et al.
Publicado: (2014)

CAR exosomes derived from effector CAR-T cells have potent antitumour effects and low toxicity
por: Fu, Wenyan, et al.
Publicado: (2019)

Moscatilin Suppresses the Breast Cancer Both In Vitro and In Vivo by Inhibiting HDAC3
por: Su, Wenjie, et al.
Publicado: (2021)

Suppression of Spry1 inhibits triple-negative breast cancer malignancy by decreasing EGF/EGFR mediated mesenchymal phenotype
por: He, Qing, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_0ea8v1lqpf04i56v8dlblhnf7v