Effect of Eriodictyol on Collagen-Induced Arthritis in Rats by Akt/HIF-1α Pathway

PURPOSE: The aim of the experiment was to explore the effect of eriodictyol (ERI) on arthritis. METHODS: We established a rat model of collagen-induced rheumatoid arthritis (CIA) using type II collagen plus Freund’s complete adjuvant. We evaluated the degree of paw swelling, joint pathology, inflamm...

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Autores principales: Lei, ZhongHua, Ouyang, Liu, Gong, Yong, Wang, ZhaoZhen, Yu, Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7196781/
https://www.ncbi.nlm.nih.gov/pubmed/32425508
http://dx.doi.org/10.2147/DDDT.S239662
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author Lei, ZhongHua
Ouyang, Liu
Gong, Yong
Wang, ZhaoZhen
Yu, Bo
author_facet Lei, ZhongHua
Ouyang, Liu
Gong, Yong
Wang, ZhaoZhen
Yu, Bo
author_sort Lei, ZhongHua
collection PubMed
description PURPOSE: The aim of the experiment was to explore the effect of eriodictyol (ERI) on arthritis. METHODS: We established a rat model of collagen-induced rheumatoid arthritis (CIA) using type II collagen plus Freund’s complete adjuvant. We evaluated the degree of paw swelling, joint pathology, inflammatory cytokine levels, and the Akt/hypoxia-inducible factor (HIF)-1α signaling pathway in the CIA rats. RESULTS: ERI significantly ameliorated joint swelling; improved joint pathology; and suppressed the release of interleukin-6, interleukin-1 beta, and tumor necrosis factor-alpha. Moreover, ERI inhibited the Akt/HIF-1α pathway in the joints of rats and in lipopolysaccharide-treated RAW264.7 cells. CONCLUSION: ERI ameliorated arthritis in a manner involving the Akt/HIF-1α signaling pathway.
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spelling pubmed-71967812020-05-18 Effect of Eriodictyol on Collagen-Induced Arthritis in Rats by Akt/HIF-1α Pathway Lei, ZhongHua Ouyang, Liu Gong, Yong Wang, ZhaoZhen Yu, Bo Drug Des Devel Ther Original Research PURPOSE: The aim of the experiment was to explore the effect of eriodictyol (ERI) on arthritis. METHODS: We established a rat model of collagen-induced rheumatoid arthritis (CIA) using type II collagen plus Freund’s complete adjuvant. We evaluated the degree of paw swelling, joint pathology, inflammatory cytokine levels, and the Akt/hypoxia-inducible factor (HIF)-1α signaling pathway in the CIA rats. RESULTS: ERI significantly ameliorated joint swelling; improved joint pathology; and suppressed the release of interleukin-6, interleukin-1 beta, and tumor necrosis factor-alpha. Moreover, ERI inhibited the Akt/HIF-1α pathway in the joints of rats and in lipopolysaccharide-treated RAW264.7 cells. CONCLUSION: ERI ameliorated arthritis in a manner involving the Akt/HIF-1α signaling pathway. Dove 2020-04-29 /pmc/articles/PMC7196781/ /pubmed/32425508 http://dx.doi.org/10.2147/DDDT.S239662 Text en © 2020 Lei et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Lei, ZhongHua
Ouyang, Liu
Gong, Yong
Wang, ZhaoZhen
Yu, Bo
Effect of Eriodictyol on Collagen-Induced Arthritis in Rats by Akt/HIF-1α Pathway
title Effect of Eriodictyol on Collagen-Induced Arthritis in Rats by Akt/HIF-1α Pathway
title_full Effect of Eriodictyol on Collagen-Induced Arthritis in Rats by Akt/HIF-1α Pathway
title_fullStr Effect of Eriodictyol on Collagen-Induced Arthritis in Rats by Akt/HIF-1α Pathway
title_full_unstemmed Effect of Eriodictyol on Collagen-Induced Arthritis in Rats by Akt/HIF-1α Pathway
title_short Effect of Eriodictyol on Collagen-Induced Arthritis in Rats by Akt/HIF-1α Pathway
title_sort effect of eriodictyol on collagen-induced arthritis in rats by akt/hif-1α pathway
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7196781/
https://www.ncbi.nlm.nih.gov/pubmed/32425508
http://dx.doi.org/10.2147/DDDT.S239662
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