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Risk of Recurrence and Transition to Chronic Disease in Acute Central Serous Chorioretinopathy

PURPOSE: To study the risk of recurrence in acute central serous chorioretinopathy (aCSC) and to evaluate the risk of transitioning to chronic CSC. PATIENTS AND METHODS: The medical records and multimodal imaging data of 295 aCSC cases were reviewed. Typical aCSC was defined as the presence of serou...

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Autores principales: Mohabati, Danial, Boon, Camiel J F, Yzer, Suzanne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7196815/
https://www.ncbi.nlm.nih.gov/pubmed/32425502
http://dx.doi.org/10.2147/OPTH.S242926
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author Mohabati, Danial
Boon, Camiel J F
Yzer, Suzanne
author_facet Mohabati, Danial
Boon, Camiel J F
Yzer, Suzanne
author_sort Mohabati, Danial
collection PubMed
description PURPOSE: To study the risk of recurrence in acute central serous chorioretinopathy (aCSC) and to evaluate the risk of transitioning to chronic CSC. PATIENTS AND METHODS: The medical records and multimodal imaging data of 295 aCSC cases were reviewed. Typical aCSC was defined as the presence of serous subretinal fluid (SRF), one focal leakage spot on fluorescein angiography (FA), retinal pigment epithelium (RPE) alterations limited in area to less than one optic disc diameter, and complete recovery from this first CSC episode. An increase in RPE alterations combined with persistent SRF was considered a sign of chronicity, which was determined in cases with >12 months follow-up. The main outcome measures included final visual acuity, percentage of disease recurrence, and percentage of cases moving toward a chronic phenotype. Treatment strategies and their efficacy were also reviewed. RESULTS: A total of 295 eyes in 291 patients with aCSC were included. Spontaneous recovery was awaited in 154 eyes (52%), whereas 141 eyes (48%) recovered following treatment. SRF recurrence occurred in 24% of untreated cases and in 4% of treated cases (p<0.001). An analysis of 61 eyes that underwent an FA after ≥12 months of follow-up revealed increased RPE alterations in 22 eyes (36%), and 14 eyes (23%) had both an increase in RPE alterations and SRF recurrence. CONCLUSION: All aCSC cases recovered from the first disease episode, and none of the cases developed persistent SRF leakage. Among the cases for which long-term follow-up information was available, 36% showed a tendency toward chronicity in terms of increased RPE alterations, whereas 23% showed both an increase in RPE alterations and recurrent SRF. Early photodynamic therapy (PDT) may decrease the risk of recurrences.
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spelling pubmed-71968152020-05-18 Risk of Recurrence and Transition to Chronic Disease in Acute Central Serous Chorioretinopathy Mohabati, Danial Boon, Camiel J F Yzer, Suzanne Clin Ophthalmol Original Research PURPOSE: To study the risk of recurrence in acute central serous chorioretinopathy (aCSC) and to evaluate the risk of transitioning to chronic CSC. PATIENTS AND METHODS: The medical records and multimodal imaging data of 295 aCSC cases were reviewed. Typical aCSC was defined as the presence of serous subretinal fluid (SRF), one focal leakage spot on fluorescein angiography (FA), retinal pigment epithelium (RPE) alterations limited in area to less than one optic disc diameter, and complete recovery from this first CSC episode. An increase in RPE alterations combined with persistent SRF was considered a sign of chronicity, which was determined in cases with >12 months follow-up. The main outcome measures included final visual acuity, percentage of disease recurrence, and percentage of cases moving toward a chronic phenotype. Treatment strategies and their efficacy were also reviewed. RESULTS: A total of 295 eyes in 291 patients with aCSC were included. Spontaneous recovery was awaited in 154 eyes (52%), whereas 141 eyes (48%) recovered following treatment. SRF recurrence occurred in 24% of untreated cases and in 4% of treated cases (p<0.001). An analysis of 61 eyes that underwent an FA after ≥12 months of follow-up revealed increased RPE alterations in 22 eyes (36%), and 14 eyes (23%) had both an increase in RPE alterations and SRF recurrence. CONCLUSION: All aCSC cases recovered from the first disease episode, and none of the cases developed persistent SRF leakage. Among the cases for which long-term follow-up information was available, 36% showed a tendency toward chronicity in terms of increased RPE alterations, whereas 23% showed both an increase in RPE alterations and recurrent SRF. Early photodynamic therapy (PDT) may decrease the risk of recurrences. Dove 2020-04-29 /pmc/articles/PMC7196815/ /pubmed/32425502 http://dx.doi.org/10.2147/OPTH.S242926 Text en © 2020 Mohabati et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Mohabati, Danial
Boon, Camiel J F
Yzer, Suzanne
Risk of Recurrence and Transition to Chronic Disease in Acute Central Serous Chorioretinopathy
title Risk of Recurrence and Transition to Chronic Disease in Acute Central Serous Chorioretinopathy
title_full Risk of Recurrence and Transition to Chronic Disease in Acute Central Serous Chorioretinopathy
title_fullStr Risk of Recurrence and Transition to Chronic Disease in Acute Central Serous Chorioretinopathy
title_full_unstemmed Risk of Recurrence and Transition to Chronic Disease in Acute Central Serous Chorioretinopathy
title_short Risk of Recurrence and Transition to Chronic Disease in Acute Central Serous Chorioretinopathy
title_sort risk of recurrence and transition to chronic disease in acute central serous chorioretinopathy
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7196815/
https://www.ncbi.nlm.nih.gov/pubmed/32425502
http://dx.doi.org/10.2147/OPTH.S242926
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