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HNF1A recruits KDM6A to activate differentiated acinar cell programs that suppress pancreatic cancer
Defects in transcriptional regulators of pancreatic exocrine differentiation have been implicated in pancreatic tumorigenesis, but the molecular mechanisms are poorly understood. The locus encoding the transcription factor HNF1A harbors susceptibility variants for pancreatic ductal adenocarcinoma (P...
Autores principales: | Kalisz, Mark, Bernardo, Edgar, Beucher, Anthony, Maestro, Miguel Angel, del Pozo, Natalia, Millán, Irene, Haeberle, Lena, Schlensog, Martin, Safi, Sami Alexander, Knoefel, Wolfram Trudo, Grau, Vanessa, de Vas, Matías, Shpargel, Karl B, Vaquero, Eva, Magnuson, Terry, Ortega, Sagrario, Esposito, Irene, Real, Francisco X, Ferrer, Jorge |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7196917/ https://www.ncbi.nlm.nih.gov/pubmed/32154941 http://dx.doi.org/10.15252/embj.2019102808 |
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