Uncoupling endosomal CLC chloride/proton exchange causes severe neurodegeneration

CLC chloride/proton exchangers may support acidification of endolysosomes and raise their luminal Cl(−) concentration. Disruption of endosomal ClC‐3 causes severe neurodegeneration. To assess the importance of ClC‐3 Cl(−)/H(+) exchange, we now generate Clcn3 (unc/unc) mice in which ClC‐3 is converte...

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Detalles Bibliográficos
Autores principales: Weinert, Stefanie, Gimber, Niclas, Deuschel, Dorothea, Stuhlmann, Till, Puchkov, Dmytro, Farsi, Zohreh, Ludwig, Carmen F, Novarino, Gaia, López‐Cayuqueo, Karen I, Planells‐Cases, Rosa, Jentsch, Thomas J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7196918/
https://www.ncbi.nlm.nih.gov/pubmed/32118314
http://dx.doi.org/10.15252/embj.2019103358

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7196918/
https://www.ncbi.nlm.nih.gov/pubmed/32118314
http://dx.doi.org/10.15252/embj.2019103358

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