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Heparan sulfate proteoglycans regulate BMP signalling during neural crest induction
Bone morphogenetic protein (BMP) signalling is key to many developmental processes, including early regionalisation of the ectoderm. The neural crest is induced here by a combination of BMP and Wnt signals from nearby tissues with many secreted factors contributing to its initial specification at th...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7196931/ https://www.ncbi.nlm.nih.gov/pubmed/31883440 http://dx.doi.org/10.1016/j.ydbio.2019.12.015 |
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author | Pegge, James Tatsinkam, Arnold Junior Rider, Christopher C. Bell, Esther |
author_facet | Pegge, James Tatsinkam, Arnold Junior Rider, Christopher C. Bell, Esther |
author_sort | Pegge, James |
collection | PubMed |
description | Bone morphogenetic protein (BMP) signalling is key to many developmental processes, including early regionalisation of the ectoderm. The neural crest is induced here by a combination of BMP and Wnt signals from nearby tissues with many secreted factors contributing to its initial specification at the neural plate border. Gremlin 1 (Grem1) is a secreted BMP antagonist expressed in the neural crest in Xenopus laevis but its function here is unknown. As well as binding BMPs, Grem1 has been shown to interact with heparan sulfate proteoglycans (HSPGs), a family of cell surface macromolecules that regulate a diverse array of signalling molecules by affecting their availability and mode of action. This study describes the impact of HSPGs on the function of Grem1 in neural crest induction. It shows for the first time that Grem1 is required for neural crest development in a two-step process comprising an early HSPG-independent, followed by a late HSPG-dependent phase. |
format | Online Article Text |
id | pubmed-7196931 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-71969312020-05-05 Heparan sulfate proteoglycans regulate BMP signalling during neural crest induction Pegge, James Tatsinkam, Arnold Junior Rider, Christopher C. Bell, Esther Dev Biol Article Bone morphogenetic protein (BMP) signalling is key to many developmental processes, including early regionalisation of the ectoderm. The neural crest is induced here by a combination of BMP and Wnt signals from nearby tissues with many secreted factors contributing to its initial specification at the neural plate border. Gremlin 1 (Grem1) is a secreted BMP antagonist expressed in the neural crest in Xenopus laevis but its function here is unknown. As well as binding BMPs, Grem1 has been shown to interact with heparan sulfate proteoglycans (HSPGs), a family of cell surface macromolecules that regulate a diverse array of signalling molecules by affecting their availability and mode of action. This study describes the impact of HSPGs on the function of Grem1 in neural crest induction. It shows for the first time that Grem1 is required for neural crest development in a two-step process comprising an early HSPG-independent, followed by a late HSPG-dependent phase. Elsevier 2020-04-15 /pmc/articles/PMC7196931/ /pubmed/31883440 http://dx.doi.org/10.1016/j.ydbio.2019.12.015 Text en © 2020 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Pegge, James Tatsinkam, Arnold Junior Rider, Christopher C. Bell, Esther Heparan sulfate proteoglycans regulate BMP signalling during neural crest induction |
title | Heparan sulfate proteoglycans regulate BMP signalling during neural crest induction |
title_full | Heparan sulfate proteoglycans regulate BMP signalling during neural crest induction |
title_fullStr | Heparan sulfate proteoglycans regulate BMP signalling during neural crest induction |
title_full_unstemmed | Heparan sulfate proteoglycans regulate BMP signalling during neural crest induction |
title_short | Heparan sulfate proteoglycans regulate BMP signalling during neural crest induction |
title_sort | heparan sulfate proteoglycans regulate bmp signalling during neural crest induction |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7196931/ https://www.ncbi.nlm.nih.gov/pubmed/31883440 http://dx.doi.org/10.1016/j.ydbio.2019.12.015 |
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