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Parallel Generalized Suffix Tree Construction for Genomic Data

After a decade of digitization and technological advancements, we have an abundance of usable genomic data, which provide unique insights into our well-being. However, such datasets are large in volume, and retrieving meaningful information from them is often challenging. Hence, different indexing t...

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Detalles Bibliográficos
Autores principales: Aziz, Md Momin Al, Thulasiraman, Parimala, Mohammed, Noman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7197101/
http://dx.doi.org/10.1007/978-3-030-42266-0_1
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author Aziz, Md Momin Al
Thulasiraman, Parimala
Mohammed, Noman
author_facet Aziz, Md Momin Al
Thulasiraman, Parimala
Mohammed, Noman
author_sort Aziz, Md Momin Al
collection PubMed
description After a decade of digitization and technological advancements, we have an abundance of usable genomic data, which provide unique insights into our well-being. However, such datasets are large in volume, and retrieving meaningful information from them is often challenging. Hence, different indexing techniques and data structures have been proposed to handle such a massive scale of data. We utilize one such technique: Generalized Suffix Tree (GST). In this paper, we introduce an efficient parallel generalized suffix tree construction algorithm that is scalable for arbitrary genomic datasets. Our construction mechanism employs shared and distributed memory architecture collectively while not posing any fixed, prior memory requirement as it uses external memory (disks). Our experimental results show that our proposed architecture offers around 4-times speedup with respect to the sequential algorithm with only 16 parallel processors. The experiments on different datasets and parameters also exhibit the scalability of the execution time. In addition, we utilize different string queries and demonstrate their execution time on such tree structure, illustrating the efficacy and usability of GST for genomic data.
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spelling pubmed-71971012020-05-04 Parallel Generalized Suffix Tree Construction for Genomic Data Aziz, Md Momin Al Thulasiraman, Parimala Mohammed, Noman Algorithms for Computational Biology Article After a decade of digitization and technological advancements, we have an abundance of usable genomic data, which provide unique insights into our well-being. However, such datasets are large in volume, and retrieving meaningful information from them is often challenging. Hence, different indexing techniques and data structures have been proposed to handle such a massive scale of data. We utilize one such technique: Generalized Suffix Tree (GST). In this paper, we introduce an efficient parallel generalized suffix tree construction algorithm that is scalable for arbitrary genomic datasets. Our construction mechanism employs shared and distributed memory architecture collectively while not posing any fixed, prior memory requirement as it uses external memory (disks). Our experimental results show that our proposed architecture offers around 4-times speedup with respect to the sequential algorithm with only 16 parallel processors. The experiments on different datasets and parameters also exhibit the scalability of the execution time. In addition, we utilize different string queries and demonstrate their execution time on such tree structure, illustrating the efficacy and usability of GST for genomic data. 2020-02-01 /pmc/articles/PMC7197101/ http://dx.doi.org/10.1007/978-3-030-42266-0_1 Text en © Springer Nature Switzerland AG 2020 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Aziz, Md Momin Al
Thulasiraman, Parimala
Mohammed, Noman
Parallel Generalized Suffix Tree Construction for Genomic Data
title Parallel Generalized Suffix Tree Construction for Genomic Data
title_full Parallel Generalized Suffix Tree Construction for Genomic Data
title_fullStr Parallel Generalized Suffix Tree Construction for Genomic Data
title_full_unstemmed Parallel Generalized Suffix Tree Construction for Genomic Data
title_short Parallel Generalized Suffix Tree Construction for Genomic Data
title_sort parallel generalized suffix tree construction for genomic data
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7197101/
http://dx.doi.org/10.1007/978-3-030-42266-0_1
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