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Prevalence of positive TST among healthcare workers in high-burden TB setting in Peru

BACKGROUND: Tuberculosis (TB) transmission has long been recognized as an important occupational hazard for healthcare workers (HCWs). HCWs have a 5.8% annual risk of exposure and three times greater risk of developing active TB than the general population. METHODS: We conducted an observational cro...

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Autores principales: Sedamano, Juana, Schwalb, Alvaro, Cachay, Rodrigo, Zamudio, Carlos, Ugarte-Gil, César, Soto-Cabezas, Gabriela, Munayco, César V., Seas, Carlos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7197122/
https://www.ncbi.nlm.nih.gov/pubmed/32362276
http://dx.doi.org/10.1186/s12889-020-08756-9
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author Sedamano, Juana
Schwalb, Alvaro
Cachay, Rodrigo
Zamudio, Carlos
Ugarte-Gil, César
Soto-Cabezas, Gabriela
Munayco, César V.
Seas, Carlos
author_facet Sedamano, Juana
Schwalb, Alvaro
Cachay, Rodrigo
Zamudio, Carlos
Ugarte-Gil, César
Soto-Cabezas, Gabriela
Munayco, César V.
Seas, Carlos
author_sort Sedamano, Juana
collection PubMed
description BACKGROUND: Tuberculosis (TB) transmission has long been recognized as an important occupational hazard for healthcare workers (HCWs). HCWs have a 5.8% annual risk of exposure and three times greater risk of developing active TB than the general population. METHODS: We conducted an observational cross-sectional study between September 2014 and March 2015 among HCWs in a high-burden TB setting in Lima to estimate the prevalence of positive Tuberculin Skin Test (TST) and to investigate factors associated with a positive TST. RESULTS: Two hundred forty participants were included in the analysis; TST was administered to 190 (79.2%) while the rest were exempt due to a previous positive TST result, history of TB, or test refusal. A positive TST result was found among 56.2% of participants to whom the TST was applied (95% CI: 49.22–63.55%). When considering those who had a previous positive TST result and those with a history of TB, the prevalence of a positive TST result was 64.3% (95% CI: 57.8–70.3%). No significant differences were observed between clinical/paramedical and administrative staff in the health center. The use of N95 masks during work hours was reported by 142 (69.9%) participants. Prevalence ratios (PR) show that workers with more than 120 months as a HCW were 1.44 times more likely to be TST positive. The multivariate analysis found that HCWs with over 10 years of service were 1.52 times more likely to be TST positive. CONCLUSION: This study supports previous reports that TB infection is an occupational hazard for HCWs. Prevention of TB transmission through control measures, as well as timely diagnosis of LTBI in this particular high-risk group, is critical for individual and public health.
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spelling pubmed-71971222020-05-08 Prevalence of positive TST among healthcare workers in high-burden TB setting in Peru Sedamano, Juana Schwalb, Alvaro Cachay, Rodrigo Zamudio, Carlos Ugarte-Gil, César Soto-Cabezas, Gabriela Munayco, César V. Seas, Carlos BMC Public Health Research Article BACKGROUND: Tuberculosis (TB) transmission has long been recognized as an important occupational hazard for healthcare workers (HCWs). HCWs have a 5.8% annual risk of exposure and three times greater risk of developing active TB than the general population. METHODS: We conducted an observational cross-sectional study between September 2014 and March 2015 among HCWs in a high-burden TB setting in Lima to estimate the prevalence of positive Tuberculin Skin Test (TST) and to investigate factors associated with a positive TST. RESULTS: Two hundred forty participants were included in the analysis; TST was administered to 190 (79.2%) while the rest were exempt due to a previous positive TST result, history of TB, or test refusal. A positive TST result was found among 56.2% of participants to whom the TST was applied (95% CI: 49.22–63.55%). When considering those who had a previous positive TST result and those with a history of TB, the prevalence of a positive TST result was 64.3% (95% CI: 57.8–70.3%). No significant differences were observed between clinical/paramedical and administrative staff in the health center. The use of N95 masks during work hours was reported by 142 (69.9%) participants. Prevalence ratios (PR) show that workers with more than 120 months as a HCW were 1.44 times more likely to be TST positive. The multivariate analysis found that HCWs with over 10 years of service were 1.52 times more likely to be TST positive. CONCLUSION: This study supports previous reports that TB infection is an occupational hazard for HCWs. Prevention of TB transmission through control measures, as well as timely diagnosis of LTBI in this particular high-risk group, is critical for individual and public health. BioMed Central 2020-05-03 /pmc/articles/PMC7197122/ /pubmed/32362276 http://dx.doi.org/10.1186/s12889-020-08756-9 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
Sedamano, Juana
Schwalb, Alvaro
Cachay, Rodrigo
Zamudio, Carlos
Ugarte-Gil, César
Soto-Cabezas, Gabriela
Munayco, César V.
Seas, Carlos
Prevalence of positive TST among healthcare workers in high-burden TB setting in Peru
title Prevalence of positive TST among healthcare workers in high-burden TB setting in Peru
title_full Prevalence of positive TST among healthcare workers in high-burden TB setting in Peru
title_fullStr Prevalence of positive TST among healthcare workers in high-burden TB setting in Peru
title_full_unstemmed Prevalence of positive TST among healthcare workers in high-burden TB setting in Peru
title_short Prevalence of positive TST among healthcare workers in high-burden TB setting in Peru
title_sort prevalence of positive tst among healthcare workers in high-burden tb setting in peru
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7197122/
https://www.ncbi.nlm.nih.gov/pubmed/32362276
http://dx.doi.org/10.1186/s12889-020-08756-9
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