Suppressor mutations in Mecp2-null mice implicate the DNA damage response in Rett syndrome pathology

Mutations in X-linked methyl-CpG-binding protein 2 (MECP2) cause Rett syndrome (RTT). To identify functional pathways that could inform therapeutic entry points, we carried out a genetic screen for secondary mutations that improved phenotypes in Mecp2/Y mice after mutagenesis with N-ethyl-N-nitrosou...

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Detalles Bibliográficos
Autores principales: Enikanolaiye, Adebola, Ruston, Julie, Zeng, Rong, Taylor, Christine, Schrock, Marijke, Buchovecky, Christie M., Shendure, Jay, Acar, Elif, Justice, Monica J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7197480/
https://www.ncbi.nlm.nih.gov/pubmed/32317254
http://dx.doi.org/10.1101/gr.258400.119

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