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Divergence-Based Introgression Polarization

Introgressive hybridization results in the transfer of genetic material between species, often with fitness implications for the recipient species. The development of statistical methods for detecting the signatures of historical introgression in whole-genome data has been a major area of focus. Alt...

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Autores principales: Forsythe, Evan S, Sloan, Daniel B, Beilstein, Mark A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7197497/
https://www.ncbi.nlm.nih.gov/pubmed/32219392
http://dx.doi.org/10.1093/gbe/evaa053
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author Forsythe, Evan S
Sloan, Daniel B
Beilstein, Mark A
author_facet Forsythe, Evan S
Sloan, Daniel B
Beilstein, Mark A
author_sort Forsythe, Evan S
collection PubMed
description Introgressive hybridization results in the transfer of genetic material between species, often with fitness implications for the recipient species. The development of statistical methods for detecting the signatures of historical introgression in whole-genome data has been a major area of focus. Although existing techniques are able to identify the taxa that exchanged genes during introgression using a four-taxon system, most methods do not explicitly distinguish which taxon served as donor and which as recipient during introgression (i.e., polarization of introgression directionality). Existing methods that do polarize introgression are often only able to do so when there is a fifth taxon available and that taxon is sister to one of the taxa involved in introgression. Here, we present divergence-based introgression polarization (DIP), a method for polarizing introgression using patterns of sequence divergence across whole genomes, which operates in a four-taxon context. Thus, DIP can be applied to infer the directionality of introgression when additional taxa are not available. We use simulations to show that DIP can polarize introgression and identify potential sources of bias in the assignment of directionality, and we apply DIP to a well-described hominin introgression event.
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spelling pubmed-71974972020-05-07 Divergence-Based Introgression Polarization Forsythe, Evan S Sloan, Daniel B Beilstein, Mark A Genome Biol Evol Research Article Introgressive hybridization results in the transfer of genetic material between species, often with fitness implications for the recipient species. The development of statistical methods for detecting the signatures of historical introgression in whole-genome data has been a major area of focus. Although existing techniques are able to identify the taxa that exchanged genes during introgression using a four-taxon system, most methods do not explicitly distinguish which taxon served as donor and which as recipient during introgression (i.e., polarization of introgression directionality). Existing methods that do polarize introgression are often only able to do so when there is a fifth taxon available and that taxon is sister to one of the taxa involved in introgression. Here, we present divergence-based introgression polarization (DIP), a method for polarizing introgression using patterns of sequence divergence across whole genomes, which operates in a four-taxon context. Thus, DIP can be applied to infer the directionality of introgression when additional taxa are not available. We use simulations to show that DIP can polarize introgression and identify potential sources of bias in the assignment of directionality, and we apply DIP to a well-described hominin introgression event. Oxford University Press 2020-03-27 /pmc/articles/PMC7197497/ /pubmed/32219392 http://dx.doi.org/10.1093/gbe/evaa053 Text en © The Author(s) 2020. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Forsythe, Evan S
Sloan, Daniel B
Beilstein, Mark A
Divergence-Based Introgression Polarization
title Divergence-Based Introgression Polarization
title_full Divergence-Based Introgression Polarization
title_fullStr Divergence-Based Introgression Polarization
title_full_unstemmed Divergence-Based Introgression Polarization
title_short Divergence-Based Introgression Polarization
title_sort divergence-based introgression polarization
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7197497/
https://www.ncbi.nlm.nih.gov/pubmed/32219392
http://dx.doi.org/10.1093/gbe/evaa053
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