SARS-CoV-2 can induce brain and spine demyelinating lesions

SARS-CoV-2 can attack the central nervous system in the early stages of infection. Headache, anosmia, and dysgeusia are common symptoms. Disturbance of consciousness and seizures can occur as complications in case of severe COVID-19. We described the case of a COVID-19 patient admitted for interstit...

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Autores principales: Zanin, Luca, Saraceno, Giorgio, Panciani, Pier Paolo, Renisi, Giulia, Signorini, Liana, Migliorati, Karol, Fontanella, Marco Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Vienna 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7197630/
https://www.ncbi.nlm.nih.gov/pubmed/32367205
http://dx.doi.org/10.1007/s00701-020-04374-x
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author Zanin, Luca
Saraceno, Giorgio
Panciani, Pier Paolo
Renisi, Giulia
Signorini, Liana
Migliorati, Karol
Fontanella, Marco Maria
author_facet Zanin, Luca
Saraceno, Giorgio
Panciani, Pier Paolo
Renisi, Giulia
Signorini, Liana
Migliorati, Karol
Fontanella, Marco Maria
author_sort Zanin, Luca
collection PubMed
description SARS-CoV-2 can attack the central nervous system in the early stages of infection. Headache, anosmia, and dysgeusia are common symptoms. Disturbance of consciousness and seizures can occur as complications in case of severe COVID-19. We described the case of a COVID-19 patient admitted for interstitial pneumonia and seizures. MRI showed newly diagnosed demyelinating lesions. High-dose steroid treatment allowed neurological and respiratory recovery. We speculated a delayed immune response induced by SARS-CoV-2. The virus may lead to a SIRS-like immune disorder or play a role of infective trigger. Prompt invasive treatment should be adopted to avoid hypoxic neurotoxicity and prevent CNS injuries.
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spelling pubmed-71976302020-05-05 SARS-CoV-2 can induce brain and spine demyelinating lesions Zanin, Luca Saraceno, Giorgio Panciani, Pier Paolo Renisi, Giulia Signorini, Liana Migliorati, Karol Fontanella, Marco Maria Acta Neurochir (Wien) Case Report SARS-CoV-2 can attack the central nervous system in the early stages of infection. Headache, anosmia, and dysgeusia are common symptoms. Disturbance of consciousness and seizures can occur as complications in case of severe COVID-19. We described the case of a COVID-19 patient admitted for interstitial pneumonia and seizures. MRI showed newly diagnosed demyelinating lesions. High-dose steroid treatment allowed neurological and respiratory recovery. We speculated a delayed immune response induced by SARS-CoV-2. The virus may lead to a SIRS-like immune disorder or play a role of infective trigger. Prompt invasive treatment should be adopted to avoid hypoxic neurotoxicity and prevent CNS injuries. Springer Vienna 2020-05-04 2020 /pmc/articles/PMC7197630/ /pubmed/32367205 http://dx.doi.org/10.1007/s00701-020-04374-x Text en © Springer-Verlag GmbH Austria, part of Springer Nature 2020 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Case Report
Zanin, Luca
Saraceno, Giorgio
Panciani, Pier Paolo
Renisi, Giulia
Signorini, Liana
Migliorati, Karol
Fontanella, Marco Maria
SARS-CoV-2 can induce brain and spine demyelinating lesions
title SARS-CoV-2 can induce brain and spine demyelinating lesions
title_full SARS-CoV-2 can induce brain and spine demyelinating lesions
title_fullStr SARS-CoV-2 can induce brain and spine demyelinating lesions
title_full_unstemmed SARS-CoV-2 can induce brain and spine demyelinating lesions
title_short SARS-CoV-2 can induce brain and spine demyelinating lesions
title_sort sars-cov-2 can induce brain and spine demyelinating lesions
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7197630/
https://www.ncbi.nlm.nih.gov/pubmed/32367205
http://dx.doi.org/10.1007/s00701-020-04374-x
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