Cargando…
Disease Severity-Associated Gene Expression in Canine Myxomatous Mitral Valve Disease Is Dominated by TGFβ Signaling
Myxomatous mitral valve disease (MMVD) is the most common acquired canine cardiovascular disease and shares many similarities with human mitral valvulopathies. While transcriptomic datasets are available for the end-stage disease in both species, there is no information on how gene expression change...
Autores principales: | Markby, Greg R., Macrae, Vicky E., Summers, Kim M., Corcoran, Brendan M. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7197751/ https://www.ncbi.nlm.nih.gov/pubmed/32395121 http://dx.doi.org/10.3389/fgene.2020.00372 |
Ejemplares similares
-
Comparative Transcriptomic Profiling and Gene Expression for Myxomatous Mitral Valve Disease in the Dog and Human
por: Markby, Greg R., et al.
Publicado: (2017) -
Evaluation of canine 2D cell cultures as models of myxomatous mitral valve degeneration
por: Tan, Karen, et al.
Publicado: (2019) -
TGF-β phospho antibody array identifies altered SMAD2, PI3K/AKT/SMAD, and RAC signaling contribute to the pathogenesis of myxomatous mitral valve disease
por: McNair, Andrew J., et al.
Publicado: (2023) -
Comparative transcriptomic profiling of myxomatous mitral valve disease in the cavalier King Charles spaniel
por: Markby, G. R., et al.
Publicado: (2020) -
TGF‐β‐induced PI3K/AKT/mTOR pathway controls myofibroblast differentiation and secretory phenotype of valvular interstitial cells through the modulation of cellular senescence in a naturally occurring in vitro canine model of myxomatous mitral valve disease
por: Tang, Qiyu, et al.
Publicado: (2023)