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The mammalian cytosolic thioredoxin reductase pathway acts via a membrane protein to reduce ER-localised proteins
Folding of proteins entering the mammalian secretory pathway requires the insertion of the correct disulfides. Disulfide formation involves both an oxidative pathway for their insertion and a reductive pathway to remove incorrectly formed disulfides. Reduction of these disulfides is crucial for corr...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Company of Biologists Ltd
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7197872/ https://www.ncbi.nlm.nih.gov/pubmed/32184267 http://dx.doi.org/10.1242/jcs.241976 |