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Persistent double strand break accumulation does not precede cell death in an Olaparib-sensitive BRCA-deficient colorectal cancer cell model

The poly (adenosine diphosphate (ADP)-ribosyl) polymerase inhibitors (PARPi) selectively kill cancer cells with BRCA1 or BRCA2 (BRCA)-mutations. It has been proposed that cell death induction after PARPi depends on unrepaired double strand breaks (DSBs) that accumulate due to the homologous recombin...

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Detalles Bibliográficos
Autores principales:	Paviolo, Natalia Soledad, de la Vega, María Belén, Pansa, María Florencia, García, Iris Alejandra, Calzetta, Nicolás Luis, Soria, Gastón, Gottifredi, Vanesa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Sociedade Brasileira de Genética 2019
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7198003/ https://www.ncbi.nlm.nih.gov/pubmed/31930278 http://dx.doi.org/10.1590/1678-4685-GMB-2019-0070

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