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From yeast to humans: Understanding the biology of DNA Damage Response (DDR) kinases

The DNA Damage Response (DDR) is a complex network of biological processes that protect cells from accumulating aberrant DNA structures, thereby maintaining genomic stability and, as a consequence, preventing the development of cancer and other diseases. The DDR pathway is coordinated by a signaling...

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Autores principales: Cussiol, José Renato Rosa, Soares, Bárbara Luísa, de Oliveira, Francisco Meirelles Bastos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Genética 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7198005/
https://www.ncbi.nlm.nih.gov/pubmed/31930279
http://dx.doi.org/10.1590/1678-4685-GMB-2019-0071
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author Cussiol, José Renato Rosa
Soares, Bárbara Luísa
de Oliveira, Francisco Meirelles Bastos
author_facet Cussiol, José Renato Rosa
Soares, Bárbara Luísa
de Oliveira, Francisco Meirelles Bastos
author_sort Cussiol, José Renato Rosa
collection PubMed
description The DNA Damage Response (DDR) is a complex network of biological processes that protect cells from accumulating aberrant DNA structures, thereby maintaining genomic stability and, as a consequence, preventing the development of cancer and other diseases. The DDR pathway is coordinated by a signaling cascade mediated by the PI3K-like kinases (PIKK) ATM and ATR and by their downstream kinases CHK2 and CHK1, respectively. Together, these kinases regulate several aspects of the cellular program in response to genomic stress. Much of our understanding of these kinases came from studies performed in the 1990s using yeast as a model organism. The purpose of this review is to present a historical perspective on the discovery of the DDR kinases in yeast and the importance of this model for the identification and functional understanding of their mammalian orthologues.
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spelling pubmed-71980052020-05-08 From yeast to humans: Understanding the biology of DNA Damage Response (DDR) kinases Cussiol, José Renato Rosa Soares, Bárbara Luísa de Oliveira, Francisco Meirelles Bastos Genet Mol Biol Articles The DNA Damage Response (DDR) is a complex network of biological processes that protect cells from accumulating aberrant DNA structures, thereby maintaining genomic stability and, as a consequence, preventing the development of cancer and other diseases. The DDR pathway is coordinated by a signaling cascade mediated by the PI3K-like kinases (PIKK) ATM and ATR and by their downstream kinases CHK2 and CHK1, respectively. Together, these kinases regulate several aspects of the cellular program in response to genomic stress. Much of our understanding of these kinases came from studies performed in the 1990s using yeast as a model organism. The purpose of this review is to present a historical perspective on the discovery of the DDR kinases in yeast and the importance of this model for the identification and functional understanding of their mammalian orthologues. Sociedade Brasileira de Genética 2019-12-13 /pmc/articles/PMC7198005/ /pubmed/31930279 http://dx.doi.org/10.1590/1678-4685-GMB-2019-0071 Text en Copyright © 2019, Sociedade Brasileira de Genética. https://creativecommons.org/licenses/by/4.0/ License information: This is an open-access article distributed under the terms of the Creative Commons Attribution License (type CC-BY), which permits unrestricted use, distribution and reproduction in any medium, provided the original article is properly cited.
spellingShingle Articles
Cussiol, José Renato Rosa
Soares, Bárbara Luísa
de Oliveira, Francisco Meirelles Bastos
From yeast to humans: Understanding the biology of DNA Damage Response (DDR) kinases
title From yeast to humans: Understanding the biology of DNA Damage Response (DDR) kinases
title_full From yeast to humans: Understanding the biology of DNA Damage Response (DDR) kinases
title_fullStr From yeast to humans: Understanding the biology of DNA Damage Response (DDR) kinases
title_full_unstemmed From yeast to humans: Understanding the biology of DNA Damage Response (DDR) kinases
title_short From yeast to humans: Understanding the biology of DNA Damage Response (DDR) kinases
title_sort from yeast to humans: understanding the biology of dna damage response (ddr) kinases
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7198005/
https://www.ncbi.nlm.nih.gov/pubmed/31930279
http://dx.doi.org/10.1590/1678-4685-GMB-2019-0071
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