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High-resolution HLA phased haplotype frequencies to predict the success of unrelated donor searches and clinical outcome following hematopoietic stem cell transplantation
HLA matching is a critical factor for successful allogeneic hematopoietic stem cell transplantation. For unrelated donor searches, matching is usually based on high-resolution typing at five HLA loci, looking for a 10/10 match. Some studies have proposed that further matching at the haplotype level...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7198472/ https://www.ncbi.nlm.nih.gov/pubmed/30953025 http://dx.doi.org/10.1038/s41409-019-0520-6 |
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author | Buhler, Stéphane Baldomero, Helen Ferrari-Lacraz, Sylvie Nunes, José Manuel Sanchez-Mazas, Alicia Massouridi-Levrat, Stravroula Heim, Dominik Halter, Jörg Nair, Gayathri Chalandon, Yves Schanz, Urs Güngör, Tayfun Nicoloso, Grazia Tiercy, Jean-Marie Passweg, Jakob Villard, Jean |
author_facet | Buhler, Stéphane Baldomero, Helen Ferrari-Lacraz, Sylvie Nunes, José Manuel Sanchez-Mazas, Alicia Massouridi-Levrat, Stravroula Heim, Dominik Halter, Jörg Nair, Gayathri Chalandon, Yves Schanz, Urs Güngör, Tayfun Nicoloso, Grazia Tiercy, Jean-Marie Passweg, Jakob Villard, Jean |
author_sort | Buhler, Stéphane |
collection | PubMed |
description | HLA matching is a critical factor for successful allogeneic hematopoietic stem cell transplantation. For unrelated donor searches, matching is usually based on high-resolution typing at five HLA loci, looking for a 10/10 match. Some studies have proposed that further matching at the haplotype level could be beneficial for clinical outcome. In this study, we determined the phased haplotypes of 291 patients using family members and segregation analysis. The sum of ranks of the haplotypes carried by patients was used as a surrogate predictor of a successful unrelated donor search. The putative impact of haplotypes was then analyzed in a cohort of 211 recipients transplanted with 10/10 matched unrelated donors. A logistic regression analysis showed a highly significant effect of the haplotypes in the outcome of a search, but we did not find any significant effect on overall survival, graft versus host disease or relapse/progression following HSCT. This study provides useful data for the optimization of unrelated bone marrow donor searches, but does not confirm previous reports that matching at the haplotype level has a clinical impact following HSCT. Due to the extreme polymorphism of HLA genes, further studies are warranted to better understand the many factors at play. |
format | Online Article Text |
id | pubmed-7198472 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-71984722020-05-06 High-resolution HLA phased haplotype frequencies to predict the success of unrelated donor searches and clinical outcome following hematopoietic stem cell transplantation Buhler, Stéphane Baldomero, Helen Ferrari-Lacraz, Sylvie Nunes, José Manuel Sanchez-Mazas, Alicia Massouridi-Levrat, Stravroula Heim, Dominik Halter, Jörg Nair, Gayathri Chalandon, Yves Schanz, Urs Güngör, Tayfun Nicoloso, Grazia Tiercy, Jean-Marie Passweg, Jakob Villard, Jean Bone Marrow Transplant Article HLA matching is a critical factor for successful allogeneic hematopoietic stem cell transplantation. For unrelated donor searches, matching is usually based on high-resolution typing at five HLA loci, looking for a 10/10 match. Some studies have proposed that further matching at the haplotype level could be beneficial for clinical outcome. In this study, we determined the phased haplotypes of 291 patients using family members and segregation analysis. The sum of ranks of the haplotypes carried by patients was used as a surrogate predictor of a successful unrelated donor search. The putative impact of haplotypes was then analyzed in a cohort of 211 recipients transplanted with 10/10 matched unrelated donors. A logistic regression analysis showed a highly significant effect of the haplotypes in the outcome of a search, but we did not find any significant effect on overall survival, graft versus host disease or relapse/progression following HSCT. This study provides useful data for the optimization of unrelated bone marrow donor searches, but does not confirm previous reports that matching at the haplotype level has a clinical impact following HSCT. Due to the extreme polymorphism of HLA genes, further studies are warranted to better understand the many factors at play. Nature Publishing Group UK 2019-04-05 2019 /pmc/articles/PMC7198472/ /pubmed/30953025 http://dx.doi.org/10.1038/s41409-019-0520-6 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Buhler, Stéphane Baldomero, Helen Ferrari-Lacraz, Sylvie Nunes, José Manuel Sanchez-Mazas, Alicia Massouridi-Levrat, Stravroula Heim, Dominik Halter, Jörg Nair, Gayathri Chalandon, Yves Schanz, Urs Güngör, Tayfun Nicoloso, Grazia Tiercy, Jean-Marie Passweg, Jakob Villard, Jean High-resolution HLA phased haplotype frequencies to predict the success of unrelated donor searches and clinical outcome following hematopoietic stem cell transplantation |
title | High-resolution HLA phased haplotype frequencies to predict the success of unrelated donor searches and clinical outcome following hematopoietic stem cell transplantation |
title_full | High-resolution HLA phased haplotype frequencies to predict the success of unrelated donor searches and clinical outcome following hematopoietic stem cell transplantation |
title_fullStr | High-resolution HLA phased haplotype frequencies to predict the success of unrelated donor searches and clinical outcome following hematopoietic stem cell transplantation |
title_full_unstemmed | High-resolution HLA phased haplotype frequencies to predict the success of unrelated donor searches and clinical outcome following hematopoietic stem cell transplantation |
title_short | High-resolution HLA phased haplotype frequencies to predict the success of unrelated donor searches and clinical outcome following hematopoietic stem cell transplantation |
title_sort | high-resolution hla phased haplotype frequencies to predict the success of unrelated donor searches and clinical outcome following hematopoietic stem cell transplantation |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7198472/ https://www.ncbi.nlm.nih.gov/pubmed/30953025 http://dx.doi.org/10.1038/s41409-019-0520-6 |
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