Formate induces a metabolic switch in nucleotide and energy metabolism

Formate is a precursor for the de novo synthesis of purine and deoxythymidine nucleotides. Formate also interacts with energy metabolism by promoting the synthesis of adenine nucleotides. Here we use theoretical modelling together with metabolomics analysis to investigate the link between formate, n...

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Detalles Bibliográficos
Autores principales: Oizel, Kristell, Tait-Mulder, Jacqueline, Fernandez-de-Cossio-Diaz, Jorge, Pietzke, Matthias, Brunton, Holly, Lilla, Sergio, Dhayade, Sandeep, Athineos, Dimitri, Blanco, Giovanny Rodriguez, Sumpton, David, Mackay, Gillian M., Blyth, Karen, Zanivan, Sara R., Meiser, Johannes, Vazquez, Alexei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7198490/
https://www.ncbi.nlm.nih.gov/pubmed/32366892
http://dx.doi.org/10.1038/s41419-020-2523-z

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