Cargando…

Diversity in medullary thymic epithelial cells controls the activity and availability of iNKT cells

The thymus supports multiple αβ T cell lineages that are functionally distinct, but mechanisms that control this multifaceted development are poorly understood. Here we examine medullary thymic epithelial cell (mTEC) heterogeneity and its influence on CD1d-restricted iNKT cells. We find three distin...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lucas, Beth, White, Andrea J., Cosway, Emilie J., Parnell, Sonia M., James, Kieran D., Jones, Nick D., Ohigashi, Izumi, Takahama, Yousuke, Jenkinson, William E., Anderson, Graham
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7198500/ https://www.ncbi.nlm.nih.gov/pubmed/32366944 http://dx.doi.org/10.1038/s41467-020-16041-x

Ejemplares similares

An Essential Role for Medullary Thymic Epithelial Cells during the Intrathymic Development of Invariant NKT Cells
por: White, Andrea J., et al.
Publicado: (2014)

Serial progression of cortical and medullary thymic epithelial microenvironments
por: Alves, Nuno L, et al.
Publicado: (2014)

Formation of the Intrathymic Dendritic Cell Pool Requires CCL21-Mediated Recruitment of CCR7(+) Progenitors to the Thymus
por: Cosway, Emilie J., et al.
Publicado: (2018)

Specific impact of β5t on proteasome subunit composition in cortical thymic epithelial cells
por: Ohigashi, Izumi, et al.
Publicado: (2021)

TCR signal strength controls thymic differentiation of iNKT cell subsets
por: Tuttle, Kathryn D., et al.
Publicado: (2018)

Control of the thymic medulla and its influence on αβT‐cell development
por: Lucas, Beth, et al.
Publicado: (2016)

Developmental Dynamics of Post-Selection Thymic DN iNKT
por: Yassai, Maryam, et al.
Publicado: (2012)

A single-cell analysis of thymopoiesis and thymic iNKT cell development in pigs
por: Gu, Weihong, et al.
Publicado: (2022)

Thymic stromal lymphopoietin production in DN32.D3 invariant natural killer T (iNKT) cell line and primary mouse liver iNKT cells
por: Choi, Jun-Pyo, et al.
Publicado: (2021)

Thymic iNKT single cell analyses unmask the common developmental program of mouse innate T cells
por: Harsha Krovi, S., et al.
Publicado: (2020)

NKT10 cells: a novel iNKT cell subset
por: Wingender, Gerhard, et al.
Publicado: (2015)

A novel method to identify Post‐Aire stages of medullary thymic epithelial cell differentiation
por: Ferreirinha, Pedro, et al.
Publicado: (2020)

Aire-dependent production of XCL1 mediates medullary accumulation of thymic dendritic cells and contributes to regulatory T cell development
por: Lei, Yu, et al.
Publicado: (2011)

iNKT and MAIT Cell Alterations in Diabetes
por: Magalhaes, Isabelle, et al.
Publicado: (2015)

The Role of Autophagy in iNKT Cell Development
por: Yang, Guan, et al.
Publicado: (2018)

Recent advances in iNKT cell development
por: Hogquist, Kristin, et al.
Publicado: (2020)

Embryonic keratin19(+) progenitors generate multiple functionally distinct progeny to maintain epithelial diversity in the adult thymus medulla
por: Lucas, Beth, et al.
Publicado: (2023)

Graphene oxide polarizes iNKT cells for production of TGFβ and attenuates inflammation in an iNKT cell-mediated sepsis model
por: Lee, Sung Won, et al.
Publicado: (2018)

Regeneration of invariant natural killer T (iNKT) cells: application of iPSC technology for iNKT cell-targeted tumor immunotherapy
por: Aoki, Takahiro, et al.
Publicado: (2023)

RIPK1 deficiency prevents thymic NK1.1 expression and subsequent iNKT cell development
por: Hägglöf, Thomas, et al.
Publicado: (2023)

CD24(+) Cell Depletion Permits Effective Enrichment of Thymic iNKT Cells While Preserving Their Subset Composition
por: Park, Joo-Young, et al.
Publicado: (2019)

The iNKT Cell–Macrophage Axis in Homeostasis and Disease
por: Cruz, Mariana S., et al.
Publicado: (2022)

The Timing and Abundance of IL-2Rβ (CD122) Expression Control Thymic iNKT Cell Generation and NKT1 Subset Differentiation
por: Won, Hee Yeun, et al.
Publicado: (2021)

Enhancing Neuroblastoma Immunotherapies by Engaging iNKT and NK Cells
por: McNerney, Kevin O., et al.
Publicado: (2020)

NNKTT120, an anti-iNKT cell monoclonal antibody, produces rapid and sustained iNKT cell depletion in adults with sickle cell disease
por: Field, Joshua J., et al.
Publicado: (2017)

β-Catenin is required for the differentiation of iNKT2 and iNKT17 cells that augment IL-25-dependent lung inflammation
por: Berga-Bolaños, Rosa, et al.
Publicado: (2015)

CD8(+) T-cell immunity orchestrated by iNKT cells
por: Qin, Yingyu, et al.
Publicado: (2023)

Natural Th17 cells are critically regulated by functional medullary thymic microenvironments
por: Jenkinson, William E., et al.
Publicado: (2015)

Fine-tuning of β-catenin in mouse thymic epithelial cells is required for postnatal T-cell development
por: Fujimori, Sayumi, et al.
Publicado: (2022)

The Ras/MAPK Pathway Is Required for Generation of iNKT Cells
por: Hu, Taishan, et al.
Publicado: (2011)

The transcriptional repressor NKAP is required for the development of iNKT cells
por: Thapa, Puspa, et al.
Publicado: (2013)

Histone deacetylase 3 is required for iNKT cell development
por: Thapa, Puspa, et al.
Publicado: (2017)

Alterations of the iNKT cell compartment in brain-injured patients
por: Patinec, Allan, et al.
Publicado: (2019)

The impact of stress on the transcriptomic signature of iNKT1 cells
por: Papadogianni, Georgia, et al.
Publicado: (2021)

Human iNKT Cells Modulate Macrophage Survival and Phenotype
por: Loureiro, J. Pedro, et al.
Publicado: (2022)

New insights into iNKT cells and their roles in liver diseases
por: Gu, Xinyu, et al.
Publicado: (2022)

Diversity in Cortical Thymic Epithelial Cells Occurs through Loss of a Foxn1-Dependent Gene Signature Driven by Stage-Specific Thymocyte Cross-Talk
por: White, Andrea J., et al.
Publicado: (2023)

Tissue-specific shaping of the TCR repertoire and antigen specificity of iNKT cells
por: Jimeno, Rebeca, et al.
Publicado: (2019)

Impaired thymic iNKT cell differentiation at early precursor stage in murine haploidentical bone marrow transplantation with GvHD
por: Zhao, Weijia, et al.
Publicado: (2023)

A Novel Mouse Model of iNKT Cell-deficiency Generated by CRISPR/Cas9 Reveals a Pathogenic Role of iNKT Cells in Metabolic Disease
por: Ren, Yue, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_eo3ughdf5oc1qhfi9e8d4menjd