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Deubiquitinase USP47-stabilized splicing factor IK regulates the splicing of ATM pre-mRNA
IK depletion leads to an aberrant mitotic entry because of chromosomal misalignment through the enhancement of Aurora B activity at the interphase. Here, we demonstrate that IK, a spliceosomal component, plays a crucial role in the proper splicing of the ATM pre-mRNA among other genes related with t...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7198525/ https://www.ncbi.nlm.nih.gov/pubmed/32377397 http://dx.doi.org/10.1038/s41420-020-0268-1 |