Impact of numerical variation, allele burden, mutation length and co-occurring mutations on the efficacy of tyrosine kinase inhibitors in newly diagnosed FLT3- mutant acute myeloid leukemia

FLT3-ITD mutations in newly diagnosed acute myeloid leukemia (AML) are associated with worse overall survival (OS). FLT3-ITD diversity can further influence clinical outcomes. Addition of FLT3 inhibitors to standard chemotherapy has improved OS. The aim of this study is to evaluate the prognostic im...

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Detalles Bibliográficos
Autores principales: Abou Dalle, Iman, Ghorab, Ahmad, Patel, Keyur, Wang, Xuemei, Hwang, Hyunsoo, Cortes, Jorge, Issa, Ghayas C., Yalniz, Fevzi, Sasaki, Koji, Chihara, Dai, Price, Allyson, Kadia, Tapan, Pemmaraju, Naveen, Daver, Naval, DiNardo, Courtney, Ravandi, Farhad, Kantarjian, Hagop M., Borthakur, Gautam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7198530/
https://www.ncbi.nlm.nih.gov/pubmed/32366841
http://dx.doi.org/10.1038/s41408-020-0318-1

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