A human monoclonal antibody blocking SARS-CoV-2 infection

The emergence of the novel human coronavirus SARS-CoV-2 in Wuhan, China has caused a worldwide epidemic of respiratory disease (COVID-19). Vaccines and targeted therapeutics for treatment of this disease are currently lacking. Here we report a human monoclonal antibody that neutralizes SARS-CoV-2 (a...

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Autores principales: Wang, Chunyan, Li, Wentao, Drabek, Dubravka, Okba, Nisreen M. A., van Haperen, Rien, Osterhaus, Albert D. M. E., van Kuppeveld, Frank J. M., Haagmans, Bart L., Grosveld, Frank, Bosch, Berend-Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7198537/
https://www.ncbi.nlm.nih.gov/pubmed/32366817
http://dx.doi.org/10.1038/s41467-020-16256-y
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author Wang, Chunyan
Li, Wentao
Drabek, Dubravka
Okba, Nisreen M. A.
van Haperen, Rien
Osterhaus, Albert D. M. E.
van Kuppeveld, Frank J. M.
Haagmans, Bart L.
Grosveld, Frank
Bosch, Berend-Jan
author_facet Wang, Chunyan
Li, Wentao
Drabek, Dubravka
Okba, Nisreen M. A.
van Haperen, Rien
Osterhaus, Albert D. M. E.
van Kuppeveld, Frank J. M.
Haagmans, Bart L.
Grosveld, Frank
Bosch, Berend-Jan
author_sort Wang, Chunyan
collection PubMed
description The emergence of the novel human coronavirus SARS-CoV-2 in Wuhan, China has caused a worldwide epidemic of respiratory disease (COVID-19). Vaccines and targeted therapeutics for treatment of this disease are currently lacking. Here we report a human monoclonal antibody that neutralizes SARS-CoV-2 (and SARS-CoV) in cell culture. This cross-neutralizing antibody targets a communal epitope on these viruses and may offer potential for prevention and treatment of COVID-19.
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spelling pubmed-71985372020-05-06 A human monoclonal antibody blocking SARS-CoV-2 infection Wang, Chunyan Li, Wentao Drabek, Dubravka Okba, Nisreen M. A. van Haperen, Rien Osterhaus, Albert D. M. E. van Kuppeveld, Frank J. M. Haagmans, Bart L. Grosveld, Frank Bosch, Berend-Jan Nat Commun Article The emergence of the novel human coronavirus SARS-CoV-2 in Wuhan, China has caused a worldwide epidemic of respiratory disease (COVID-19). Vaccines and targeted therapeutics for treatment of this disease are currently lacking. Here we report a human monoclonal antibody that neutralizes SARS-CoV-2 (and SARS-CoV) in cell culture. This cross-neutralizing antibody targets a communal epitope on these viruses and may offer potential for prevention and treatment of COVID-19. Nature Publishing Group UK 2020-05-04 /pmc/articles/PMC7198537/ /pubmed/32366817 http://dx.doi.org/10.1038/s41467-020-16256-y Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Wang, Chunyan
Li, Wentao
Drabek, Dubravka
Okba, Nisreen M. A.
van Haperen, Rien
Osterhaus, Albert D. M. E.
van Kuppeveld, Frank J. M.
Haagmans, Bart L.
Grosveld, Frank
Bosch, Berend-Jan
A human monoclonal antibody blocking SARS-CoV-2 infection
title A human monoclonal antibody blocking SARS-CoV-2 infection
title_full A human monoclonal antibody blocking SARS-CoV-2 infection
title_fullStr A human monoclonal antibody blocking SARS-CoV-2 infection
title_full_unstemmed A human monoclonal antibody blocking SARS-CoV-2 infection
title_short A human monoclonal antibody blocking SARS-CoV-2 infection
title_sort human monoclonal antibody blocking sars-cov-2 infection
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7198537/
https://www.ncbi.nlm.nih.gov/pubmed/32366817
http://dx.doi.org/10.1038/s41467-020-16256-y
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