The heterocyclic compound Tempol inhibits the growth of cancer cells by interfering with glutamine metabolism

Tempol (4-hydroxy-2,2,6,6-Tetramethylpiperidine-1-oxyl, TPL), a nitroxide compound, inhibits proliferation and increases the vulnerability of cancer cells to apoptosis induced by cytotoxic agents. However, the molecular mechanism of TPL inhibiting cancer cell proliferation has not been fully underst...

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Detalles Bibliográficos
Autores principales: Ye, Shuangyan, Xu, Pengfei, Huang, Mengqiu, Chen, Xi, Zeng, Sisi, Wang, Qianli, Chen, Jianping, Li, Keyi, Gao, Wenwen, Liu, Ruiyuan, Liu, Jingxian, Shao, Yihao, Zhang, Hui, Xu, Yang, Zhang, Qianbing, Zhong, Zhuo, Wei, Zibo, Wang, Jiale, Hao, Bingtao, Huang, Wenhua, Liu, Qiuzhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7198543/
https://www.ncbi.nlm.nih.gov/pubmed/32366855
http://dx.doi.org/10.1038/s41419-020-2499-8

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