Integrative analysis of Mendelian randomization and Bayesian colocalization highlights four genes with putative BMI-mediated causal pathways to diabetes

Genome-wide association studies have identified hundreds of single nucleotide polymorphisms (SNPs) that are associated with BMI and diabetes. However, lack of adequate data has for long time prevented investigations on the pathogenesis of diabetes where BMI was a mediator of the genetic causal effec...

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Detalles Bibliográficos
Autores principales: Liu, Qian, Pan, Jianxin, Berzuini, Carlo, Rutter, Martin K., Guo, Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7198550/
https://www.ncbi.nlm.nih.gov/pubmed/32366963
http://dx.doi.org/10.1038/s41598-020-64493-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7198550/
https://www.ncbi.nlm.nih.gov/pubmed/32366963
http://dx.doi.org/10.1038/s41598-020-64493-4

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