Genomic landscape of platinum resistant and sensitive testicular cancers

While most testicular germ cell tumours (TGCTs) exhibit exquisite sensitivity to platinum chemotherapy, ~10% are platinum resistant. To gain insight into the underlying mechanisms, we undertake whole exome sequencing and copy number analysis in 40 tumours from 26 cases with platinum-resistant TGCT,...

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Detalles Bibliográficos
Autores principales: Loveday, Chey, Litchfield, Kevin, Proszek, Paula Z., Cornish, Alex J., Santo, Flavia, Levy, Max, Macintyre, Geoff, Holryod, Amy, Broderick, Peter, Dudakia, Darshna, Benton, Barbara, Bakir, Maise Al, Hiley, Crispin, Grist, Emily, Swanton, Charles, Huddart, Robert, Powles, Tom, Chowdhury, Simon, Shipley, Janet, O’Connor, Simon, Brenton, James D., Reid, Alison, de Castro, David Gonzalez, Houlston, Richard S., Turnbull, Clare
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7198558/
https://www.ncbi.nlm.nih.gov/pubmed/32366847
http://dx.doi.org/10.1038/s41467-020-15768-x

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