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Inflammatory dilated cardiomyopathy: Etiology and clinical management
Inflammatory dilated cardiomyopathy (DCMi) is a syndrome, not an etiological disease entity. The infective etiology and the immunopathology can be best determined through endomyocardial biopsy with a complete work-up by light microscopy, immunohistology, and polymerase chain reaction for microbial a...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Springer Medizin
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7198648/ https://www.ncbi.nlm.nih.gov/pubmed/32123933 http://dx.doi.org/10.1007/s00059-020-04900-8 |
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author | Maisch, Bernhard Pankuweit, Sabine |
author_facet | Maisch, Bernhard Pankuweit, Sabine |
author_sort | Maisch, Bernhard |
collection | PubMed |
description | Inflammatory dilated cardiomyopathy (DCMi) is a syndrome, not an etiological disease entity. The infective etiology and the immunopathology can be best determined through endomyocardial biopsy with a complete work-up by light microscopy, immunohistology, and polymerase chain reaction for microbial agents. This review focuses on the methodological advances in diagnosis in the past few years and exemplifies the importance of an etiology-orientated treatment in different case scenarios. In fulminant nonviral myocarditis, immunosuppressive treatment together with hemodynamic stabilization of the patient via mechanical circulatory support (e.g., microaxial pumps, extracorporeal membrane oxygenation, left ventricular assist device) can be life-saving. For viral inflammatory cardiomyopathy, intravenous immunoglobulin treatment can resolve inflammation and often eradicate the virus. |
format | Online Article Text |
id | pubmed-7198648 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Springer Medizin |
record_format | MEDLINE/PubMed |
spelling | pubmed-71986482020-05-05 Inflammatory dilated cardiomyopathy: Etiology and clinical management Maisch, Bernhard Pankuweit, Sabine Herz Main Topic Inflammatory dilated cardiomyopathy (DCMi) is a syndrome, not an etiological disease entity. The infective etiology and the immunopathology can be best determined through endomyocardial biopsy with a complete work-up by light microscopy, immunohistology, and polymerase chain reaction for microbial agents. This review focuses on the methodological advances in diagnosis in the past few years and exemplifies the importance of an etiology-orientated treatment in different case scenarios. In fulminant nonviral myocarditis, immunosuppressive treatment together with hemodynamic stabilization of the patient via mechanical circulatory support (e.g., microaxial pumps, extracorporeal membrane oxygenation, left ventricular assist device) can be life-saving. For viral inflammatory cardiomyopathy, intravenous immunoglobulin treatment can resolve inflammation and often eradicate the virus. Springer Medizin 2020-03-02 2020 /pmc/articles/PMC7198648/ /pubmed/32123933 http://dx.doi.org/10.1007/s00059-020-04900-8 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Main Topic Maisch, Bernhard Pankuweit, Sabine Inflammatory dilated cardiomyopathy: Etiology and clinical management |
title | Inflammatory dilated cardiomyopathy: Etiology and clinical management |
title_full | Inflammatory dilated cardiomyopathy: Etiology and clinical management |
title_fullStr | Inflammatory dilated cardiomyopathy: Etiology and clinical management |
title_full_unstemmed | Inflammatory dilated cardiomyopathy: Etiology and clinical management |
title_short | Inflammatory dilated cardiomyopathy: Etiology and clinical management |
title_sort | inflammatory dilated cardiomyopathy: etiology and clinical management |
topic | Main Topic |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7198648/ https://www.ncbi.nlm.nih.gov/pubmed/32123933 http://dx.doi.org/10.1007/s00059-020-04900-8 |
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