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Inflammatory dilated cardiomyopathy: Etiology and clinical management

Inflammatory dilated cardiomyopathy (DCMi) is a syndrome, not an etiological disease entity. The infective etiology and the immunopathology can be best determined through endomyocardial biopsy with a complete work-up by light microscopy, immunohistology, and polymerase chain reaction for microbial a...

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Autores principales: Maisch, Bernhard, Pankuweit, Sabine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Medizin 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7198648/
https://www.ncbi.nlm.nih.gov/pubmed/32123933
http://dx.doi.org/10.1007/s00059-020-04900-8
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author Maisch, Bernhard
Pankuweit, Sabine
author_facet Maisch, Bernhard
Pankuweit, Sabine
author_sort Maisch, Bernhard
collection PubMed
description Inflammatory dilated cardiomyopathy (DCMi) is a syndrome, not an etiological disease entity. The infective etiology and the immunopathology can be best determined through endomyocardial biopsy with a complete work-up by light microscopy, immunohistology, and polymerase chain reaction for microbial agents. This review focuses on the methodological advances in diagnosis in the past few years and exemplifies the importance of an etiology-orientated treatment in different case scenarios. In fulminant nonviral myocarditis, immunosuppressive treatment together with hemodynamic stabilization of the patient via mechanical circulatory support (e.g., microaxial pumps, extracorporeal membrane oxygenation, left ventricular assist device) can be life-saving. For viral inflammatory cardiomyopathy, intravenous immunoglobulin treatment can resolve inflammation and often eradicate the virus.
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spelling pubmed-71986482020-05-05 Inflammatory dilated cardiomyopathy: Etiology and clinical management Maisch, Bernhard Pankuweit, Sabine Herz Main Topic Inflammatory dilated cardiomyopathy (DCMi) is a syndrome, not an etiological disease entity. The infective etiology and the immunopathology can be best determined through endomyocardial biopsy with a complete work-up by light microscopy, immunohistology, and polymerase chain reaction for microbial agents. This review focuses on the methodological advances in diagnosis in the past few years and exemplifies the importance of an etiology-orientated treatment in different case scenarios. In fulminant nonviral myocarditis, immunosuppressive treatment together with hemodynamic stabilization of the patient via mechanical circulatory support (e.g., microaxial pumps, extracorporeal membrane oxygenation, left ventricular assist device) can be life-saving. For viral inflammatory cardiomyopathy, intravenous immunoglobulin treatment can resolve inflammation and often eradicate the virus. Springer Medizin 2020-03-02 2020 /pmc/articles/PMC7198648/ /pubmed/32123933 http://dx.doi.org/10.1007/s00059-020-04900-8 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Main Topic
Maisch, Bernhard
Pankuweit, Sabine
Inflammatory dilated cardiomyopathy: Etiology and clinical management
title Inflammatory dilated cardiomyopathy: Etiology and clinical management
title_full Inflammatory dilated cardiomyopathy: Etiology and clinical management
title_fullStr Inflammatory dilated cardiomyopathy: Etiology and clinical management
title_full_unstemmed Inflammatory dilated cardiomyopathy: Etiology and clinical management
title_short Inflammatory dilated cardiomyopathy: Etiology and clinical management
title_sort inflammatory dilated cardiomyopathy: etiology and clinical management
topic Main Topic
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7198648/
https://www.ncbi.nlm.nih.gov/pubmed/32123933
http://dx.doi.org/10.1007/s00059-020-04900-8
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