Proteolysis of Gingival Keratinocyte Cell Surface Proteins by Gingipains Secreted From Porphyromonas gingivalis – Proteomic Insights Into Mechanisms Behind Tissue Damage in the Diseased Gingiva

Porphyromonas gingivalis, the main etiologic agent of periodontitis, secretes cysteine proteases named gingipains. HRgpA and RgpB gingipains have Arg-specificity, while Kgp gingipain is Lys-specific. Together they can cleave an array of proteins and importantly contribute to the development of perio...

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Detalles Bibliográficos
Autores principales: Hočevar, Katarina, Vizovišek, Matej, Wong, Alicia, Kozieł, Joanna, Fonović, Marko, Potempa, Barbara, Lamont, Richard J., Potempa, Jan, Turk, Boris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7198712/
https://www.ncbi.nlm.nih.gov/pubmed/32411104
http://dx.doi.org/10.3389/fmicb.2020.00722

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7198712/
https://www.ncbi.nlm.nih.gov/pubmed/32411104
http://dx.doi.org/10.3389/fmicb.2020.00722

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