A Treg-Selective IL-2 Mutein Prevents the Formation of Factor VIII Inhibitors in Hemophilia Mice Treated With Factor VIII Gene Therapy

Hemophilia A is a genetic disorder that results in the deficiency of functional factor VIII protein, which plays a key role in blood coagulation. Currently, the majority of hemophilia A patients are treated with repeated infusions of factor VIII protein. Approximately 30% of severe hemophilia A pati...

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Detalles Bibliográficos
Autores principales: Chen, Alex C., Cai, Xiaohe, Li, Chong, Khoryati, Liliane, Gavin, Marc A., Miao, Carol H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7198749/
https://www.ncbi.nlm.nih.gov/pubmed/32411127
http://dx.doi.org/10.3389/fimmu.2020.00638

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