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Naturally-Occurring Canine Mammary Tumors as a Translational Model for Human Breast Cancer

Despite extensive research over many decades, human breast cancer remains a major worldwide health concern. Advances in pre-clinical and clinical research has led to significant improvements in recent years in how we manage breast cancer patients. Although survival rates of patients suffering from l...

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Autores principales: Gray, Mark, Meehan, James, Martínez-Pérez, Carlos, Kay, Charlene, Turnbull, Arran K., Morrison, Linda R., Pang, Lisa Y., Argyle, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7198768/
https://www.ncbi.nlm.nih.gov/pubmed/32411603
http://dx.doi.org/10.3389/fonc.2020.00617
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author Gray, Mark
Meehan, James
Martínez-Pérez, Carlos
Kay, Charlene
Turnbull, Arran K.
Morrison, Linda R.
Pang, Lisa Y.
Argyle, David
author_facet Gray, Mark
Meehan, James
Martínez-Pérez, Carlos
Kay, Charlene
Turnbull, Arran K.
Morrison, Linda R.
Pang, Lisa Y.
Argyle, David
author_sort Gray, Mark
collection PubMed
description Despite extensive research over many decades, human breast cancer remains a major worldwide health concern. Advances in pre-clinical and clinical research has led to significant improvements in recent years in how we manage breast cancer patients. Although survival rates of patients suffering from localized disease has improved significantly, the prognosis for patients diagnosed with metastatic disease remains poor with 5-year survival rates at only 25%. In vitro studies using immortalized cell lines and in vivo mouse models, typically using xenografted cell lines or patient derived material, are commonly used to study breast cancer. Although these techniques have undoubtedly increased our molecular understanding of breast cancer, these research models have significant limitations and have contributed to the high attrition rates seen in cancer drug discovery. It is estimated that only 3–6% of drugs that show promise in these pre-clinical models will reach clinical use. Models that can reproduce human breast cancer more accurately are needed if significant advances are to be achieved in improving cancer drug research, treatment outcomes, and prognosis. Canine mammary tumors are a naturally-occurring heterogenous group of cancers that have several features in common with human breast cancer. These similarities include etiology, signaling pathway activation and histological classification. In this review article we discuss the use of naturally-occurring canine mammary tumors as a translational animal model for human breast cancer research.
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spelling pubmed-71987682020-05-14 Naturally-Occurring Canine Mammary Tumors as a Translational Model for Human Breast Cancer Gray, Mark Meehan, James Martínez-Pérez, Carlos Kay, Charlene Turnbull, Arran K. Morrison, Linda R. Pang, Lisa Y. Argyle, David Front Oncol Oncology Despite extensive research over many decades, human breast cancer remains a major worldwide health concern. Advances in pre-clinical and clinical research has led to significant improvements in recent years in how we manage breast cancer patients. Although survival rates of patients suffering from localized disease has improved significantly, the prognosis for patients diagnosed with metastatic disease remains poor with 5-year survival rates at only 25%. In vitro studies using immortalized cell lines and in vivo mouse models, typically using xenografted cell lines or patient derived material, are commonly used to study breast cancer. Although these techniques have undoubtedly increased our molecular understanding of breast cancer, these research models have significant limitations and have contributed to the high attrition rates seen in cancer drug discovery. It is estimated that only 3–6% of drugs that show promise in these pre-clinical models will reach clinical use. Models that can reproduce human breast cancer more accurately are needed if significant advances are to be achieved in improving cancer drug research, treatment outcomes, and prognosis. Canine mammary tumors are a naturally-occurring heterogenous group of cancers that have several features in common with human breast cancer. These similarities include etiology, signaling pathway activation and histological classification. In this review article we discuss the use of naturally-occurring canine mammary tumors as a translational animal model for human breast cancer research. Frontiers Media S.A. 2020-04-28 /pmc/articles/PMC7198768/ /pubmed/32411603 http://dx.doi.org/10.3389/fonc.2020.00617 Text en Copyright © 2020 Gray, Meehan, Martínez-Pérez, Kay, Turnbull, Morrison, Pang and Argyle. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Gray, Mark
Meehan, James
Martínez-Pérez, Carlos
Kay, Charlene
Turnbull, Arran K.
Morrison, Linda R.
Pang, Lisa Y.
Argyle, David
Naturally-Occurring Canine Mammary Tumors as a Translational Model for Human Breast Cancer
title Naturally-Occurring Canine Mammary Tumors as a Translational Model for Human Breast Cancer
title_full Naturally-Occurring Canine Mammary Tumors as a Translational Model for Human Breast Cancer
title_fullStr Naturally-Occurring Canine Mammary Tumors as a Translational Model for Human Breast Cancer
title_full_unstemmed Naturally-Occurring Canine Mammary Tumors as a Translational Model for Human Breast Cancer
title_short Naturally-Occurring Canine Mammary Tumors as a Translational Model for Human Breast Cancer
title_sort naturally-occurring canine mammary tumors as a translational model for human breast cancer
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7198768/
https://www.ncbi.nlm.nih.gov/pubmed/32411603
http://dx.doi.org/10.3389/fonc.2020.00617
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