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Structural and Functional Analysis of Gly212 Mutants Reveals the Importance of Intersubunit Interactions in ASIC1a Channel Function

Acid-sensing ion channels (ASICs) act as pH sensors in neurons. ASICs contribute to pain sensation, learning, fear behavior and to neuronal death after ischemic stroke. Extracellular acidification induces a transient activation and subsequent desensitization of these Na(+)-selective channels. ASICs...

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Detalles Bibliográficos
Autores principales:	Bignucolo, Olivier, Vullo, Sabrina, Ambrosio, Nicolas, Gautschi, Ivan, Kellenberger, Stephan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Molecular Biosciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7198790/ https://www.ncbi.nlm.nih.gov/pubmed/32411719 http://dx.doi.org/10.3389/fmolb.2020.00058

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