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Insulin secretory defect may be the major determinant of GDM in lean mothers

AIMS: To compare the insulin sensitivity and secretion indices of pregnant Bangladeshi women with GDM and normal glucose tolerance (NGT). METHODS: This cross sectional study was performed with 40 GDM and equal number of NGT pregnant women diagnosed on basis of WHO criterion-2013 during 24–40 weeks o...

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Autores principales: Fakhrul-Alam, M., Sharmin-Jahan, Mashfiqul-Hasan, Nusrat-Sultana, Mohona-Zaman, Rakibul-Hasan, M., Farid-Uddin, M., Hasanat, M.A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199011/
https://www.ncbi.nlm.nih.gov/pubmed/32382513
http://dx.doi.org/10.1016/j.jcte.2020.100226
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author Fakhrul-Alam, M.
Sharmin-Jahan
Mashfiqul-Hasan
Nusrat-Sultana
Mohona-Zaman
Rakibul-Hasan, M.
Farid-Uddin, M.
Hasanat, M.A.
author_facet Fakhrul-Alam, M.
Sharmin-Jahan
Mashfiqul-Hasan
Nusrat-Sultana
Mohona-Zaman
Rakibul-Hasan, M.
Farid-Uddin, M.
Hasanat, M.A.
author_sort Fakhrul-Alam, M.
collection PubMed
description AIMS: To compare the insulin sensitivity and secretion indices of pregnant Bangladeshi women with GDM and normal glucose tolerance (NGT). METHODS: This cross sectional study was performed with 40 GDM and equal number of NGT pregnant women diagnosed on basis of WHO criterion-2013 during 24–40 weeks of gestation. Glucose was measured by glucose oxidase method and fasting insulin by chemiluminescent immunoassay. Equations of homeostatic model assessment (HOMA) were used to calculate indices of insulin resistance (HOMA-IR), β-cell function (HOMA-B) and insulin sensitivity (HOMA-%S). RESULTS: The GDM group had significantly higher insulin resistance as indicated by higher fasting insulin value [GDM vs. NGT; 10.23 (7.94–14.50) vs. 7.07 (5.28–11.07) µIU/ml] and HOMA-IR [GDM vs. NGT; 2.47 (1.75–3.43) vs. 1.50 (0.99–2.22)] and poor β-cell secretion [GDM vs. NGT; HOMA-B: 113.37 (90.30–191.35) vs. 150.98 (109.85–271.72), median (IQR); p < 0.001 for all]. HOMA-B was significantly lower in GDM than NGT with BMI < 23 kg/m(2) [GDM vs. NGT; 63.37 (49.19–83.83) vs. 134.89 (93.50–193.17) ng/ml; p = 0.010] despite having statistically comparable difference in IR. BMI was found to be a significant predictor of HOMA-IR in GDM. CONCLUSIONS: Though impairments of both insulin secretion and sensitivity are hallmarks in the pathogenesis of GDM, β-cell dysfunction contributes more to development of GDM in those with relatively lower BMI in our population.
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spelling pubmed-71990112020-05-07 Insulin secretory defect may be the major determinant of GDM in lean mothers Fakhrul-Alam, M. Sharmin-Jahan Mashfiqul-Hasan Nusrat-Sultana Mohona-Zaman Rakibul-Hasan, M. Farid-Uddin, M. Hasanat, M.A. J Clin Transl Endocrinol Research Paper AIMS: To compare the insulin sensitivity and secretion indices of pregnant Bangladeshi women with GDM and normal glucose tolerance (NGT). METHODS: This cross sectional study was performed with 40 GDM and equal number of NGT pregnant women diagnosed on basis of WHO criterion-2013 during 24–40 weeks of gestation. Glucose was measured by glucose oxidase method and fasting insulin by chemiluminescent immunoassay. Equations of homeostatic model assessment (HOMA) were used to calculate indices of insulin resistance (HOMA-IR), β-cell function (HOMA-B) and insulin sensitivity (HOMA-%S). RESULTS: The GDM group had significantly higher insulin resistance as indicated by higher fasting insulin value [GDM vs. NGT; 10.23 (7.94–14.50) vs. 7.07 (5.28–11.07) µIU/ml] and HOMA-IR [GDM vs. NGT; 2.47 (1.75–3.43) vs. 1.50 (0.99–2.22)] and poor β-cell secretion [GDM vs. NGT; HOMA-B: 113.37 (90.30–191.35) vs. 150.98 (109.85–271.72), median (IQR); p < 0.001 for all]. HOMA-B was significantly lower in GDM than NGT with BMI < 23 kg/m(2) [GDM vs. NGT; 63.37 (49.19–83.83) vs. 134.89 (93.50–193.17) ng/ml; p = 0.010] despite having statistically comparable difference in IR. BMI was found to be a significant predictor of HOMA-IR in GDM. CONCLUSIONS: Though impairments of both insulin secretion and sensitivity are hallmarks in the pathogenesis of GDM, β-cell dysfunction contributes more to development of GDM in those with relatively lower BMI in our population. Elsevier 2020-04-17 /pmc/articles/PMC7199011/ /pubmed/32382513 http://dx.doi.org/10.1016/j.jcte.2020.100226 Text en © 2020 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Research Paper
Fakhrul-Alam, M.
Sharmin-Jahan
Mashfiqul-Hasan
Nusrat-Sultana
Mohona-Zaman
Rakibul-Hasan, M.
Farid-Uddin, M.
Hasanat, M.A.
Insulin secretory defect may be the major determinant of GDM in lean mothers
title Insulin secretory defect may be the major determinant of GDM in lean mothers
title_full Insulin secretory defect may be the major determinant of GDM in lean mothers
title_fullStr Insulin secretory defect may be the major determinant of GDM in lean mothers
title_full_unstemmed Insulin secretory defect may be the major determinant of GDM in lean mothers
title_short Insulin secretory defect may be the major determinant of GDM in lean mothers
title_sort insulin secretory defect may be the major determinant of gdm in lean mothers
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199011/
https://www.ncbi.nlm.nih.gov/pubmed/32382513
http://dx.doi.org/10.1016/j.jcte.2020.100226
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