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Insulin secretory defect may be the major determinant of GDM in lean mothers
AIMS: To compare the insulin sensitivity and secretion indices of pregnant Bangladeshi women with GDM and normal glucose tolerance (NGT). METHODS: This cross sectional study was performed with 40 GDM and equal number of NGT pregnant women diagnosed on basis of WHO criterion-2013 during 24–40 weeks o...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199011/ https://www.ncbi.nlm.nih.gov/pubmed/32382513 http://dx.doi.org/10.1016/j.jcte.2020.100226 |
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author | Fakhrul-Alam, M. Sharmin-Jahan Mashfiqul-Hasan Nusrat-Sultana Mohona-Zaman Rakibul-Hasan, M. Farid-Uddin, M. Hasanat, M.A. |
author_facet | Fakhrul-Alam, M. Sharmin-Jahan Mashfiqul-Hasan Nusrat-Sultana Mohona-Zaman Rakibul-Hasan, M. Farid-Uddin, M. Hasanat, M.A. |
author_sort | Fakhrul-Alam, M. |
collection | PubMed |
description | AIMS: To compare the insulin sensitivity and secretion indices of pregnant Bangladeshi women with GDM and normal glucose tolerance (NGT). METHODS: This cross sectional study was performed with 40 GDM and equal number of NGT pregnant women diagnosed on basis of WHO criterion-2013 during 24–40 weeks of gestation. Glucose was measured by glucose oxidase method and fasting insulin by chemiluminescent immunoassay. Equations of homeostatic model assessment (HOMA) were used to calculate indices of insulin resistance (HOMA-IR), β-cell function (HOMA-B) and insulin sensitivity (HOMA-%S). RESULTS: The GDM group had significantly higher insulin resistance as indicated by higher fasting insulin value [GDM vs. NGT; 10.23 (7.94–14.50) vs. 7.07 (5.28–11.07) µIU/ml] and HOMA-IR [GDM vs. NGT; 2.47 (1.75–3.43) vs. 1.50 (0.99–2.22)] and poor β-cell secretion [GDM vs. NGT; HOMA-B: 113.37 (90.30–191.35) vs. 150.98 (109.85–271.72), median (IQR); p < 0.001 for all]. HOMA-B was significantly lower in GDM than NGT with BMI < 23 kg/m(2) [GDM vs. NGT; 63.37 (49.19–83.83) vs. 134.89 (93.50–193.17) ng/ml; p = 0.010] despite having statistically comparable difference in IR. BMI was found to be a significant predictor of HOMA-IR in GDM. CONCLUSIONS: Though impairments of both insulin secretion and sensitivity are hallmarks in the pathogenesis of GDM, β-cell dysfunction contributes more to development of GDM in those with relatively lower BMI in our population. |
format | Online Article Text |
id | pubmed-7199011 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-71990112020-05-07 Insulin secretory defect may be the major determinant of GDM in lean mothers Fakhrul-Alam, M. Sharmin-Jahan Mashfiqul-Hasan Nusrat-Sultana Mohona-Zaman Rakibul-Hasan, M. Farid-Uddin, M. Hasanat, M.A. J Clin Transl Endocrinol Research Paper AIMS: To compare the insulin sensitivity and secretion indices of pregnant Bangladeshi women with GDM and normal glucose tolerance (NGT). METHODS: This cross sectional study was performed with 40 GDM and equal number of NGT pregnant women diagnosed on basis of WHO criterion-2013 during 24–40 weeks of gestation. Glucose was measured by glucose oxidase method and fasting insulin by chemiluminescent immunoassay. Equations of homeostatic model assessment (HOMA) were used to calculate indices of insulin resistance (HOMA-IR), β-cell function (HOMA-B) and insulin sensitivity (HOMA-%S). RESULTS: The GDM group had significantly higher insulin resistance as indicated by higher fasting insulin value [GDM vs. NGT; 10.23 (7.94–14.50) vs. 7.07 (5.28–11.07) µIU/ml] and HOMA-IR [GDM vs. NGT; 2.47 (1.75–3.43) vs. 1.50 (0.99–2.22)] and poor β-cell secretion [GDM vs. NGT; HOMA-B: 113.37 (90.30–191.35) vs. 150.98 (109.85–271.72), median (IQR); p < 0.001 for all]. HOMA-B was significantly lower in GDM than NGT with BMI < 23 kg/m(2) [GDM vs. NGT; 63.37 (49.19–83.83) vs. 134.89 (93.50–193.17) ng/ml; p = 0.010] despite having statistically comparable difference in IR. BMI was found to be a significant predictor of HOMA-IR in GDM. CONCLUSIONS: Though impairments of both insulin secretion and sensitivity are hallmarks in the pathogenesis of GDM, β-cell dysfunction contributes more to development of GDM in those with relatively lower BMI in our population. Elsevier 2020-04-17 /pmc/articles/PMC7199011/ /pubmed/32382513 http://dx.doi.org/10.1016/j.jcte.2020.100226 Text en © 2020 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Research Paper Fakhrul-Alam, M. Sharmin-Jahan Mashfiqul-Hasan Nusrat-Sultana Mohona-Zaman Rakibul-Hasan, M. Farid-Uddin, M. Hasanat, M.A. Insulin secretory defect may be the major determinant of GDM in lean mothers |
title | Insulin secretory defect may be the major determinant of GDM in lean mothers |
title_full | Insulin secretory defect may be the major determinant of GDM in lean mothers |
title_fullStr | Insulin secretory defect may be the major determinant of GDM in lean mothers |
title_full_unstemmed | Insulin secretory defect may be the major determinant of GDM in lean mothers |
title_short | Insulin secretory defect may be the major determinant of GDM in lean mothers |
title_sort | insulin secretory defect may be the major determinant of gdm in lean mothers |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199011/ https://www.ncbi.nlm.nih.gov/pubmed/32382513 http://dx.doi.org/10.1016/j.jcte.2020.100226 |
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